A series of metallopurpurins was tested for their photodynamic activity against transplantable N-[4-(5-nitro-2-furyl)-2-thiazoyl]formamide-induced urothelial tumors growing in male Fischer CDF (F344/CrlBR) rats. Histological examination of tumors in animals treated with the metallopurpurins and red light (greater than 590 nm, 360 J/cm2) revealed tumor necrosis 24 h after completion of therapy. ...

Because danthron, though carcinogenic, does not seem to be genotoxic, it and 8 other hydroxyanthraquinones were comparatively investigated for activities associated with tumor promotion, such as stimulation of cell proliferation and enhancement of malignant transformation. The in vivo treatment of primary rat hepatocytes with danthron, aloe-emodin, chrysophanol, and rhein resulted in a 2-3-fold...

The brief history of photodynamic therapy (PDT) research has been focused on photosensitizers (PSs) and light delivery was introduced recently. The appropriate PSs were developed from the first generation PS Photofrin (QLT) to the second (chlorins or bacteriochlorins derivatives) and third (conjugated PSs on carrier) generations PSs to overcome undesired disadvantages, and to increase selective...

Gold nanoparticles (GNPs) conjugates of water soluble ionic photosensitizer (PS), purpurin-18-N-methyl-D-glucamine (Pu-18-NMGA), were synthesized using various molar ratios between HAuCl4 and Pu-18-NMGA without adding any particular reducing agents and surfactants. The PS-GNPs conjugates showed long wavelength absorption of range 702-762 nm, and their different shapes and diameters depend on th...

A serÃ-esof metallopurpurins was tested for their photodynamic activity against transplantable /V-[4-(5-mtro-2-furyl)-2-thia*oyl|formarnide-induced urothelial tumors growing in male Fischer CDF (F344/CrlBR) rats. HistolÃ3gica! examination of tumors in animals treated with the metallopurpurins and red light (>590 nm, 360 J/cm2) revealed tumor necrosis 24 h after completion of therapy. Control tu...

Tailored ad-hoc methods must be developed for successful identification of minute amounts of natural dyes on works of art using Surface-Enhanced Raman Spectroscopy (SERS). This article details two of these successful approaches using silver film over nanosphere (AgFON) substrates and silica gel coupled with citrate-reduced Ag colloids. The latter substrate functions as the test system for the c...

Tephrosia purpurea, (Syn: Galega purpurea, Linn.; Family: Fabaceae) is locally known as Bansa (Punjabi), Sarphunka (Hindi) and Jangli kulthi (Sindhi). It grows wild throughout Indo-Pak-Bangla Desh subcontinent on hard and stony grounds (1-3). It is branched and sub-erect herbaceous perennial plant. The plants are propagated through seeds (4, 5). Phytochemical investigations revealed the presenc...

The grave from Gokstad in Norway, dating to ca 900 AD, is one of the best-preserved Viking Age ship graves world. mound contained a variety goods along with human remains, buried ship. Several textiles, including embroideries and shreds what might have been ship’s tent, were also found. colors textile fragments are now severely faded, but high quality embroidery made gold silk threads still app...