The aim of this study was the prediction model retention indices compounds from aboveground parts Achillea clypeolata Sibth. & Sm. essential oil, obtained by hydrodistillation and analysed GC?MS. quantitative structure?retention relationship analysis applied in order to anticipate time compounds. selection seven molecular descriptors done a genetic algorithm. chosen were uncorrelated used c...

This paper is a study of the chemical composition Hyssopus officinalis ssp. grown during three years (2017–2019) at Institute Field and Vegetable Crops Novi Sad (Vojvodina Province, Serbia). Furthermore, comparisons with ISO standards were also investigated, as well prediction model retention indices compounds from essential oils. An oil obtained by hydrodistillation analysed GC-FID GC-MS was i...

Design of Experiments (DoE) is an indispensable tool in contemporary drug analysis as it simultaneously balances a number chromatographic parameters to ensure optimal separation High Pressure Liquid Chromatography (HPLC). This manuscript briefly outlines the theoretical background DOE and provides step-by-step instruction for its implementation HPLC pharmaceutical practice. It particularly disc...

The properties relevant to pharmacokinetics and pharmacodynamics of four series of synthesized s-triazine derivatives have been studied by Quantitative structure-retention relationship (QSRR) approach. The chromatographic behavior of these compounds was investigated by using reversed-phase high performance thin-layer chromatography (RP-HPTLC). Chromatographic retention (RM0) was correlated with...

A liquid chromatography method has been developed and validated for the determination of mathematical models for prediction of the lipophilicity of s-triazine compounds. Correlation between retention factors, RM 0 , of several s-triazine derivatives and their physico-chemical and structural properties has been studied by TLC on silica gel impregnated with paraffin oil. The research in this pape...

Defining the interaction of newly synthesized compounds with plasma proteins is an important step in drug development process. Chromatographic techniques can be successfully used predicting biopharmaceutical and pharmacokinetic properties compounds. The aim this study to investigate isolate most molecular that affect 20 chalcones commercial (lopinavir, ritonavir, darunavir ivermectin) human ser...