The quaternary structure stability of proteins is typically studied under conditions that accelerate their aggregation/unfolding processes on convenient laboratory time scales. Such conditions include high temperature or pressure, chaotrope-mediated unfolding, or low or high pH. These approaches have the limitation of being nonphysiological and that the concentration of the protein in solution ...

Synthesis of quaternary quantum circuits involves basic quaternary gates and logic operations in the quaternary quantum domain. In this paper, we propose new projection operations and quaternary logic gates for synthesizing quaternary logic functions. We also demonstrate the realization of the proposed gates using basic quantum quaternary operations. We then employ our synthesis method to desig...

The discussion between general practitioners (GPs) and healthcare delivery organizations necessitates a common language. The presentation of the 4 types of GP's activities, opens dialogue but can lead to possible misunderstandings between the micro- and macro-level of the healthcare system. This commentary takes 4 examples: costs reduction by P4, priority of beneficence or nonmaleficence, role ...

The foundational elements of cells and tissues are water, lipid, protein, mineral, vitamins, carbohydrates. A healthy varied diet, fortified food & nutraceuticals that provide appropriate macro micronutrients required to maintain functioning wear tear the human body. Nutraceuticals (Nutrition + pharmaceuticals) isolated nutrients or dietary supplements medical health benefits, including prevent...

Michael Glick, DMD P revention, health screening, and assessing risk are concepts that lie at the core of medicine and dentistry and affect how all of us practice. In order to apply these concepts effectively, we must be clear in defining them. Prevention can be separated into primary, secondary, tertiary, and quaternary prevention. Primary prevention usually refers to an attempt to reduce a cl...

BACKGROUND Medical overuse is a topic of growing interest in health care systems and especially in primary care. It comprises both over investigation and overtreatment. Quaternary prevention strategies aim at protecting patients from unnecessary or harmful medicine. The objective of this study was to gain a deeper understanding of relevant aspects of medical overuse in primary care from the per...