The DNA of helper-dependent coliphage P4 and the DNA of its helper-P2-show no detectable sequence homology as measured by DNA.DNA hybridization. The lack of cross-hybridization permits direct analysis of P4 as well as of P2 transcription in P4-infected P2 lysogens by RNA.DNA hybridization. P4-transactivated P2 transcription can be detected around 20 min after P4 infection of the P2 lysogen and ...

The article analyzes literature problems using as a parameter the quaternary prevention concept, introducing guidelines to have good shared decisions that avoid overdiagnosis and overtreatment and improve the quality of life. The author proposes a four-step approach: reliable evidence, awareness about populations profile, independent research analysis, and an understandable format by ordinary p...

the article of marc jamoulle shows the importance of the contribution of general practitioners (gps) in improving the quality and the efficiency of the health systems. starting from the concept of quaternary prevention for reducing excessive costs in the preventive procedures, he suggests a change of paradigm in every daily activity of the gp in order to have a stronger ethical approach to the ...

Abstract We conducted a genealogical analysis of quaternary prevention, an instrument primary health care to address overmedicalization and iatrogenesis, based on related statements interviews with the creators this concept. This tool has been used in reformulation doctor-patient relationship, but limited risk-benefit assessment by using current scientific evidence. In study, we analyze paradox...

OBJECTIVE To evaluate the effects of oral estradiol given with either oral or intravaginal micronized progesterone (P4) on risk biomarkers for breast cancer in a postmenopausal monkey model. DESIGN This experiment was a two-way crossover study in which 20 ovariectomized adult female cynomolgus macaques were treated (in equivalent doses for women) with oral estradiol (1 mg/d) + oral micronized...

Hoàng defined the P4-sparse graphs as the graphs where every set of five vertices induces at most one P4. These graphs attracted considerable attention in connection with the P4-structure of graphs and the fact that P4-sparse graphs have bounded clique-width. Fouquet and Giakoumakis generalized this class to the nicely structured semi-P4-sparse graphs being the (P5, co-P5, co-chair)-free graphs...

We study the P4-tidy graphs, a new class defined by Rusu [30] in order to illustrate the notion of P4-domination in perfect graphs. This class strictly contains the P4-extendible graphs and the P4-lite graphs defined by Jamison & Olariu in [19] and [23] and we show that the P4-tidy graphs and P4-lite graphs are closely related. Note that the class of P4-lite graphs is a class of brittle graphs ...

Circulating concentration of progesterone (P4) is determined by a balance between P4 production, primarily by corpus luteum (CL), and P4 metabolism, primarily by liver. The volume of large luteal cells in the CL is a primary factor regulating P4 production. Rate of P4 metabolism is generally determined by liver blood flow and can be of critical importance in determining circulating P4 concentra...