BACKGROUND & OBJECTIVES Levels of protective antibodies against Calpha and R4 proteins of the group B streptococci (GBS) have been measured in humans. The findings indicated that the human anti Calpha and anti-R4 antibodies may recognize targets which are different from those recognized by antibodies raised in animals. In the present study normal human serum antibodies which target the GBS prot...

Tafenoquine (TFQ), an 8-aminoquinoline used to treat and prevent Plasmodium infections, could represent an alternative therapy for leishmaniasis. Indeed, TFQ has shown significant leishmanicidal activity both in vitro and in vivo, where it targets Leishmania mitochondria and activates a final apoptosis-like process. In order not to jeopardize the life span of this potential antileishmania drug,...

There is considerable interest in pneumococcal protein antigens capable of inducing serotype-independent immunoprotection and of improving, thereby, existing vaccines. We report here on the immunogenic properties of a novel surface antigen encoded by ORF spr1875 in the R6 strain genome. An antigenic fragment encoded by spr1875, designated R4, was identified using a Streptococcus pneumoniae phag...

We show, using the methods of geometric algebra, that Runge-Lenz vector in Kepler problem is a 3-dimensional projection SO(4) moment map acts on phase space 4-dimensional particle motion. Thus, RL consequence symmetry $\mathbb{R}^4\times \mathbb{R}^4$ space.

A U(1) BF–Yang–Mills theory on noncommutative R4 is presented and in this formulation the U(1) Yang–Mills theory on noncommutative R4 is seen as a deformation of the pure BF theory. Quantization using BRST symmetry formalism is discussed and Feynman rules are given. Computations at one–loop order have been performed and their renormalization studied. It is shown that the U(1) BFYM on noncommuta...

The Cortex-R4 processor builds on this foundation, by increasing performance while keeping system costs low. This is achieved through a variety of new technologies and design improvements which increase the computing efficiency of the processor. By providing a number of synthesis time configuration options, the Cortex-R4 is able to address applications previously covered by the ARM946E-S, ARM96...

Lipoglycopeptide antibiotics are more effective than vancomycin against MRSA as they carry an extra aliphatic acyl side chain on glucosamine (Glm) at residue 4 (r4). The biosynthesis of the r4 N-acyl Glc moiety at teicoplanin (Tei) or A40926 has been elucidated, in which the primary amine nucleophile of Glm is freed from the r4 GlcNac pseudo-Tei precursor by Orf2* for the subsequent acylation r...

classes based on both: v data, and v behavior Recipe Recipe Name {I} Cooking Time Cooking Temp. Heating Rate R2 Batch Batch ID {I} Amount of Batch Recipe Name {R2} Status Temperature Ramp Ramp ID {I} Batch ID {R4} Start Temperature Start Time End Temperature End Time Status R4

To identify a set of genes involved in the development of radiation-induced tumorigenesis, we used DNA microarrays consisting of 1176 mouse genes and compared expression profiles of radioresistant cells, designated NIH3T3-R1 and NIH3T3-R4. These cells were tumorigenic in a nude mouse grafting system, as compared with the parental NIH3T3 cells. Expression of MDM2, CDK6 and CDC25B was found to in...

In mammals, facial branchiomotor (FBM) neurones are born in ventral rhombomere (r) 4 and migrate through r5 to dorsal r6 where they form the facial motor nucleus. This pattern of migration gives rise to the distinctive appearance of the internal genu of the facial nerve, which is lacking in birds. To distinguish between extrinsic cues and intrinsic factors in the caudal migration of FBM neurone...