This article proposes to study the first 12 years of the Minas Gerais Radium Institute, founded in 1922. Its work in the fight against cancer in Brazil, albeit still little known, is coming to light as its institutional documents are studied. A database has been prepared using information from its patient register, based on which statistical analyses have been done to identify the types of canc...

We evaluated the antimicrobial activities of a cationic Gemini surfactant, trans-1,4-bis[2-(alkanoyloxy)ethyldimethylammonio]-2-butene dichloride [II-m-2(t-butene)] and its derivatives against Gram-positive and Gram-negative microorganisms. The II-m-2(t-butene) compound was previously shown to have good surface activity and biodegradability. A dodecanoyloxy derivative (m = 12) of II-m-2(t-buten...

BACKGROUND Radium-223 chloride ((223)Ra; Alpharadin) is an alpha-emitting radioisotope that targets areas of osteoblastic metastasis and is excreted by the small intestine. When compared with beta-emitters (eg, strontium-89, samarium-153), (223)Ra delivers a high quantity of energy per track length with short tissue penetration. OBJECTIVE This review describes the mechanism, radiobiology, and...

OBJECTIVE RA and axial SpA have an important impact on patients' lives. The objective of this study was to explore the reporting of different aspects of that impact in publications, with a focus on differences between diseases and over time. METHODS A systematic literature review retrieved all articles reporting on the life impact of RA or axial radiographic SpA in adults published within the...

OBJECTIVES To review systematically the available literature on the optimal dosage and route of administration of methotrexate in patients with rheumatoid arthritis (RA), as an evidence base for generating clinical practice recommendations. METHODS A systematic literature search was carried out in MEDLINE, EMBASE, Cochrane Library and American College of Rheumatology/European League Against R...

background: reporting quality of research on medical education has come under scrutiny in recent years in wake of empirical evidence. poor reporting quality of published abstracts may distract readers from careful reading of research evidence or in a worst case mislead scientists. main objective of this study was to evaluate the extent and quality of the submitted abstracts to the 3rd and 4th n...

OBJECTIVES To summarise existing evidence on a target oriented approach for rheumatoid arthritis (RA) treatment. METHODS We conducted a systematic literature search including all clinical trials testing clinical, functional, or structural values of a targeted treatment approach. Our search covered Medline, Embase and Cochrane databases until December 2008 and also conference abstracts (2007, ...

introduction: most physicians consider abstracts to give a general idea about the full text of an article. abstracts, as summative and informative parts, contain main information of papers. they also point out the content of papers to readers. the importance of abstracts leads journals to be stricter about their structure and content. this study aimed to assess the abstracts of randomized contr...

OBJECTIVE To assess the relative efficacy of subsequent biologic therapies in patients with RA who have had an inadequate response to prior therapy with a TNF-α inhibitor. METHODS A systematic review was conducted using the MEDLINE, Embase and Cochrane Library databases and abstract lists from the European League Against Rheumatism, American College of Rheumatology and British Society of Rheu...