OBJECTIVE To investigate the effect of recombinant human p53 adenovirus injection combined with paclitaxel on human cervical cancer HeLa cell proliferation, apoptosis and expression of vascular endothelial growth factor (VEGF). MATERIALS AND METHODS Detection of effects of paclitaxel, rAd-p53, and drug combination on the proliferation of HeLa cells by MTT method. Detection of effects of pacli...

Lifting modules and their various generalizations as some main concepts in module theory have been studied and investigated extensively in recent decades. Some authors tried to present some homological aspects of lifting modules and -supplemented modules. In this work, we shall present a homological approach to -supplemented modules via fully invariant submodules. Lifting modules and H-suppleme...

Neste trabalho, descrevemos a obtenção de dois novos compostos de cobre(II), ou precursores, (Pr-Rad) 2 [Cu(opba)].H 2 O (1) e (Bu-Rad) 2 [Cu(opba)].2H 2 O (2), onde opba é o ligante ortofenilenobis(oxamato) e R-Rad são radicais cátions do tipo nitronil nitróxido. A partir destes compostos 1 e 2, foram sintetizados os dois novos magnetos moleculares [Pr-Rad] 2 [Mn 2 {Cu(opba)} 3 ].3,3 DMSO.5H 2...

This document discusses a numerical analysis method for low thrust trajectory propagation known as the proximity quotient or Q-Law. The process uses a Lyapunov feedback control law developed by Petropoulos [1] to propagate trajectories of spacecraft by minimizing the user defined function at the target orbit. A simplified propagator is created from the core mechanics of this method in MATLAB an...

The aim of the present study was to assess recovery from hematopoietic and gastrointestinal damage by Ex-RAD(®), also known as ON01210.Na (4-carboxystyryl-4-chlorobenzylsulfone, sodium salt), after total body radiation. In our previous study, we reported that Ex-RAD, a small-molecule radioprotectant, enhances survival of mice exposed to gamma radiation, and prevents radiation-induced apoptosis ...

Vaccines harboring genes that encode functional oncoproteins are intrinsically hazardous, as their application may lead to introduction of these genes into normal cells and thereby to tumorigenesis. On the other hand, oncoproteins are especially attractive targets for immunotherapy of cancer, as their expression is generally required for tumor growth, making the arisal of tumor variants lacking...

Národní ?asopisy jsou d?ležitým prost?edkem pro p?stování dialogu o sm??ování jednotlivých obor?. ?lenové redak?ních rad t?chto ?asopis? mohou ovlivnit kodifikaci m??ítek prací publikovaných v daném oboru, bývají proto ozna?ováni jako gatekeepers, tedy „strážci brány vybírající, který obsah a forma v?deckého sd?lení p?ijatelné“. Abychom si vytvo?ili alespo? p?ibližnou p?edstavu složení rad, m?ž...

Let A be a finite-dimensional, basic, connected algebra over an algebraically closed field. Denote by Γ (A) the Auslander–Reiten quiver of A. We show that A is representation-finite if and only if Γ (A) has at most finitely many vertices lying on oriented cycles and finitely many orbits with respect to the action of the Auslander–Reiten translation. Let K denote a fixed algebraically closed fie...

Activation of D4 receptors (D4Rs) has been shown to improve cognitive performance, potentially affecting synaptic strength. We investigated the D4R agonist PD 168077 (PD) in hippocampal CA1 of freely moving mice. We electrically stimulated in stratum oriens (OR) or radiatum (RAD) and evoked local field potentials (LFPs). Intraperitoneally injected PD dose-dependently and reversibly attenuated L...