Introduction: Hypothyroidism is one of the frequent side effects of radiotherapy of head and neck cancers, breast cancer, and Hodgkin's lymphoma. It is recommended to estimate the normal tissue complication probability of thyroid gland using radiobiological modeling during treatment planning. Moreover, the use of artificial neural network is also proposed as a new method for t...

Radiobiological researches with heavy ions have been started at ITEP in 2006 on unique heavy ion accelerating facility ITEP-TWAC. The main purpose of these researches is study of the biological efficiency of carbon ions for different types of biological objects, such as tumor and normal cells, in the framework of the development of heavy ion therapy for cancer treatment in Russia. Another possi...

diation and radiobiological researches and radiation protection. The first two lines are included in the Topical Plan for Scientific Research of JINR and were concentrated on: • neutron spectrometry and radiometry, radiation monitoring; • investigation of radiation fields around thick targets; • physical support of radiobiological experiments; • shielding calculations and design; • investigatio...

Radiobiological models are essential components of modern radiotherapy. They are increasingly applied to optimize and evaluate the quality of different treatment planning modalities. They are frequently used in designing new radiotherapy clinical trials by estimating the expected therapeutic ratio of new protocols. In radiobiology, the therapeutic ratio is estimated from the expected gain in tu...

This study aims to compare the radiobiological response of two stereotactic body radiotherapy (SBRT) schedules for patients with stage I peripheral non-small cell lung cancer (NSCLC) using radiobiological modeling methods. Volumetric modulated arc therapy (VMAT)-based SBRT plans were designed using two dose schedules of 1 × 34 Gy (34 Gy in 1 fraction) and 4 × 12 Gy (48 Gy in 4 fractions) for 19...

BACKGROUND AND PURPOSE The radiobiological parameters for liver and lung metastases treated with stereotactic body radiation therapy (SBRT) are poorly defined. This project aimed at estimating these parameters from published tumor control probability (TCP) data, and separately for metastases with colorectal cancer (CRC) and non-CRC histology. MATERIALS AND METHODS A total of 62 studies with 8...