Abstract Background Post-operative stereotactic radiosurgery (SRS) of patients with brain metastases single resection cavities is typically planned on a post-recovery MRI, 4-6 weeks after resection. However, meanwhile the intracranial metastasis may (re-)grow, and postponing adjuvant systemic treatment increases chance extracranial progression as well. Anticipating direct post-operative SRS to ...

BACKGROUND Using accurate and easy to use rapid antigen detection tests (RADTs) to identify group A beta-haemolytic Streptococci (GABHS) sore throat infections could reduce unnecessary antibiotic prescribing and antimicrobial resistance. Although there is no international consensus on the use of RADTs, these kits have been widely adopted in Finland, France and the USA. Yet in the UK, the Clinic...

INTRODUCTION In group A streptococcal (GAS) pharyngitis a ten-day course of amoxicillin is recommended. However, short-course treatments seem to be equally effective. The aim of this study was to retrospectively evaluate and compare the outcome of patients treated with 7-day course and 10-day course of amoxicillin. MATERIALS AND METHODS Retrospective analysis of all GAS pharyngitis admitted t...

OBJECTIVE To study the prevalence of Group A beta haemolytic Streptococcus in patients with acute pharyngitis and correlation of Modified Centor Score and Rapid Antigen Detection Test. METHODS The multi-centre, prospective, cross-sectional study was conducted in 8 major cities of Pakistan between June 2012 and February 2013, and comprised patients presenting with acute pharyngitis. The subjec...

In 1926 Campbell and Hanna (1) published a method for the determination of fructose based upon the reduction of molybdenum in phosphoric acid solution and the reoxidation of the reduced molybdenum with potassium permanganate. This method is not entirely specific for fructose; other substances in blood and urine have some reducing action upon the molybdic acid reagent. The method will not permit...

Thorium dioxide, when injected intravenously, is taken up by the reticulo-endothelial system and retained indefinitely, rendering the liver and spleen radio-opaque (Radt, 1930). A 25% colloidal solution of thorium dioxide was marketed under the name of "thorotrast" and used not only for hepatolienography but for retrograde pyelography, bronchography, and angiography generally, not to mention ot...

Abstract OBJECTIVES Standard of care for newly diagnosed glioblastoma after resection includes concurrent temozolomide (TMZ) and radiation therapy followed by adjuvant TTF with maintenance TMZ. Preclinical studies suggest radiotherapy work synergistically. We evaluate the benefit CRT vs TMZ CRT. METHODS Concurrent patients were enrolled in a single-arm pilot study (clinicaltrials.gov Identifier...

Abstract BACKGROUND Stereotactic Radiosurgery (SRS) has become a primary management option for brain metastases (BMs). This present study aims to review outcomes in patients with ≥ 20 BMs treated single session SRS and identify predictors of local tumor control (LTC) overall survival (OS). METHODS We identified 75 including 26 non-small cell lung cancer (NSCLC), 21 small (SCLC), 14 breast (BC),...

Abstract Purpose/Objective(s) Re-irradiation (ReRT) is often used to treat recurrent high grade glioma (HGG). There limited literature regarding the patterns of recurrence following ReRT, which was investigated in current study. Materials/METHODS Patients with available radiation (RT) contours, dosimetry, and imaging-based evidence were included retrospective All patients treated fractionated R...