0006-3207/$ see front matter 2011 Elsevier Ltd. A doi:10.1016/j.biocon.2011.06.019 ⇑ Corresponding author. Tel.: +1 506 452 6047; fax E-mail address: [email protected] (S.B. Heard). Population-level impacts of insect herbivory on rare and endangered plants are poorly understood, being frequently suggested but seldom quantified. We compiled 37 studies from the primary literature encompassing 35 rare...

A mutator is an allele that increases the mutation rate throughout the genome by disrupting some aspect of DNA replication or repair. Mutators that increase the mutation rate by the order of 100-fold have been observed to spontaneously emerge and achieve high frequencies in natural populations and in long-term laboratory evolution experiments with Escherichia coli. In principle, the fixation of...

Rare cell populations play a pivotal role in the initiation and progression of diseases such as cancer. However, the identification of such subpopulations remains a difficult task. This work describes CellCnn, a representation learning approach to detect rare cell subsets associated with disease using high-dimensional single-cell measurements. Using CellCnn, we identify paracrine signalling-, A...