The anti-mutagenic activity of a PPAR-γ ligand pioglitazone (PIO-1 and 10 mg/kg, p.o daily for 4 weeks) was evaluated against the nicotinamide (NA-230 mg/kg, ip) and streptozotocin (STZ-65 mg/kg, ip) induced nuclear damage in diabetic Wistar rats. The NA-STZ diabetes significantly (P<0.001) increased the frequency of bone marrow micronuclei in erythrocytes and reduced the P/N ratio (polychromat...

Methomyl has a significant animal and public health problem. The present study was designed to evaluate the protective effect of nicotinic acid against the acute toxic effects induced by methomyl in albino rats. Four groups were divided into control, nicotinic acid (NA) (100 mg/kg b.wt./twice daily) for 7 successive days, methomyl (MET) (8 mg/kg b.wt.) and nicotinic acid plus methomyl (NA+MET) ...

The purpose of this study was to identify food sources for major minerals such as calcium (Ca), phosphorus (P), sodium (Na) and potassium (K), and to evaluate the relationship between dietary intake of these minerals and serum lipids in healthy Korean adults. A total of 132 healthy men and women completed a physical examination and dietary record and provided blood samples for lipid profile ana...

background: today, in many countries, wastewater treatment plants effluent is an important part of the renewable water resources. in this case, the effluent quality standards are developed and used is important. the aim of this study was to investigate the potential use of wastewater plants effluent restricted irrigation. methods: in this descriptive - analytical study, samples was collected fr...

Thirty-three Collies (14 male and 19 female) were used in a doseescalation study to determine the impact of ABCB1 genotype on loperamide pharmacokinetics (PK) and pharmacodynamics (PD). Loperamide was orally administered in four ascending doses (0.01, 0.05, 0.1, or 0.2 mg/kg) over a 4-wk period to fasted Collies. Comparisons were made within each dose to genotype, phenotype, and whether Collies...

The interconversion of cell lineages via transdifferentiation is an adaptive mode of tissue regeneration and an appealing therapeutic target. However, its clinical exploitation is contingent upon the discovery of contextual regulators of cell fate acquisition and maintenance. In murine models of diabetes, glucagon-secreting alpha cells transdifferentiate into insulin-secreting beta cells follow...

BACKGROUND Stent fracture (SF) after drug-eluting stent implantation has become an important concern. The aim of this study was to assess the incidence, predictors, and clinical impact of SF after biolimus-eluting stent. METHODS AND RESULTS A total of 1026 patients with 1407 lesions undergoing the Nobori biolimus-eluting stent implantation and follow-up angiography within 9 months after index...

The effect of increasing concentrations of ivermectin on adenosine triphosphatase (ATPase) activity was investigated in adult worms of Onchocerca volvulus. Mean Mg- and Na,K-ATPase activities decreased significantly (F ratio = 29.82, P < 0.01 and F ratio = 28.54, P < 0.01, respectively) with increasing concentrations of ivermectin (0-100 ng/ml) in the female worms. When male and female worms we...

The effects of supplemental potassium were studied on growth, ion concentration and anatomical parameters in one year old olive trees, Olea europaea L., grown in sand culture in greenhouse at different levels of NaCl for 80 days. The experiments were conducted in a completely randomized design as a factorial. Factor one was salinity (0, 40 or 80 mM NaCl) and the second factor was potassium leve...

Correspondence 2 . Mayo PH , Beaulieu Y , Doelken P , et al . American College of Chest Physicians/La Société de Réanimation de Langue Française statement on competence in critical care ultrasonography . Chest . 2009 ; 135 ( 4 ): 1050 1060 . 3 . Kaplan A , Mayo PH . Echocardiography performed by the pulmo nary/critical care medicine physician . Chest . 2009 ; 135 ( 2 ): 529 535 . 4 . Schmidt GA...