Accurate estimates of the spatial and temporal variation in terrestrial water and energy fluxes and mean states are important for simulating regional hydrology and biogeochemistry in high-latitude regions. Furthermore, it is necessary to develop high-resolution hydroclimatological datasets at finer spatial resolutions than are currently available from global analyses. This study uses a regional...

Six approaches for downscaling climate model outputs for use in hydrologic simulation were evaluated, with particular emphasis on each method’s ability to produce precipitation and other variables used to drive a macroscale hydrology model applied at much higher spatial resolution than the climate model. Comparisons were made on the basis of a twenty-year retrospective (1975– 1995) climate simu...

Medium sized carbocycles are particularly difficult to synthesize. Ring closing metathesis reactions (RCM) have recently been applied to construct eight-membered carbocycles, but trisubstituted double bonds in the eight-membered rings are more difficult to produce using RCM reactions. In this review, model examples and our own results are cited and the importance of the preparation of suitably ...

BACKGROUND A herbal preparation, known as RMIT Chinese Medicine 102 (RCM-102) consisting of eight herbs which demonstrates inhibition of the release of key inflammatory mediators associated with seasonal allergic rhinitis (SAR) was used. This study evaluated the efficacy and safety of RCM-102 for SAR. OBJECTIVE This study evaluated the efficacy and safety of RCM-102 for SAR. METHODS This ra...

Maier et al. (2010) introduced the relational causal model (RCM) for representing and inferring causal relationships in relational data. A lifted representation, called abstract ground graph (AGG), plays a central role in reasoning with and learning of RCM. The correctness of the algorithm proposed by Maier et al. (2013a) for learning RCM from data relies on the soundness and completeness of AG...

Cardiomyopathies are diseases that primarily affect the myocardium, leading to serious cardiac dysfunction and heart failure. Out of the three major categories of cardiomyopathies (hypertrophic, dilated and restrictive), restrictive cardiomyopathy (RCM) is less common and also the least studied. However, the prognosis for RCM is poor as some patients dying in their childhood. The molecular mech...

By the end of the 1980s a number of large, research intensive universities in North America had begun experimenting with an organizational and budgetary concept that later became known as Responsibility Center Budgeting or Responsibility Center Management. The principal objectives of RCB/RCM were to relocate and enhance responsibility for planning and budgeting, usually by decentralization, and...

BACKGROUND The number needed to treat (NNT) ratio is an effective method for measuring accuracy in melanoma detection. Dermoscopy reduces the number of false positives and subsequently unnecessary excisions. In vivo reflectance confocal microscopy (RCM) is a noninvasive technique that allows examination of the skin with cellular resolution. OBJECTIVES To assess the impact of RCM analysis on t...

BACKGROUND Solitary pink lesions in differential diagnosis with hypopigmented/amelanotic melanoma present a diagnostic challenge in daily practice and are regularly referred for second expert opinion. Reflectance confocal microscopy (RCM) has been shown to improve diagnostic accuracy of dermoscopically equivocal pink lesions. No studies have been performed to evaluate the effect of adding a sec...

BACKGROUND Actinic cheilitis (AC) represents the equivalent of actinic keratosis on the lip. Various treatment modalities are available and the efficacy of diclofenac in hyaluronic acid has recently been described. Reflectance confocal microscopy (RCM) is a non-invasive imaging technique which has recently been applied for the diagnosis of actinic keratoses. Herein, we describe the applicabilit...