Reactive oxygen species (ROS) play a key role in a variety of biotic and abiotic stress conditions, therefore their direct measurement in vivo is of special importance. In this study, we describe two dansyl-based ROS sensors, the singlet oxygen specific DanePy; HO1889NH, which is reactive to both singlet oxygen and superoxide radicals and a rhodaminebased singlet oxygen sensor, HO-2941. In orde...

An imbalance between the formation of reactive oxygen species (ROS) and reaction antioxidant proteins is referred to as oxidative stress [...]

metals can cause oxidative stress by increasing the formation of reactive oxygen species (ros), which make antioxidants incapable of defiance against growing amounts of free radicals. metal toxicity is related to their oxidative state and reactivity with other compounds. however, several reports about metals have been published in the recent years. mitochondria, as a site of cellular oxygen con...

Oxygen is an essential element to conduct life processes but some of the metabolic byproducts e.g. reactive oxygen species (ROS), are toxic for living organisms. Endogenous ROS are produced e.g. reduction of dioxygen; some exogenous sources of radicals also exist, including nicotine and ionizing radiation. Reactive oxygen species include superoxide anion, hydroxyl radical, singlet oxygen, hydro...

INTRODUCTION Diabetic nephropathy is the leading cause of chronic kidney disease (CKD) and end-stage renal disease.1 It is characterized by initial hyperfiltration, albuminuria, thickening of the basement-membranes, expansion of the mesangial matrix, and subsequent loss of kidney function.2 Reactive oxygen species (ROS) include superoxide anion, hydrogen peroxide, and hydroxyl radical. Reactive...

arsenic exposure mainly through food and water has been shown to be associated with increased incidence of numerous cancers and non-cancer harmful health. it is also used in cancer chemotherapy and treatment of several cancer types due to its apoptogenic effects in the various cancer and normal cell lines. we have already reported that liver is the storage site and important target organ in as ...

We expose methods for in vivo assessment of oxygen, nitric oxide (NO), and reactive oxygen species (ROS)/reactive nitrogen species (RNS), in the microcirculation during normoxia and hypoxia. We provide an example of the related mechanisms of ROS/RNS and oxygen level in the process of regulating capillary perfusion. Namely, we discuss the real time pO(2) measurements in vivo in the microvessels ...

Cancer Therapy In article number 2202694, Dong-Hyun Kim and co-workers develop reactive oxygen species (ROS)–responsive biodegradable metallic nanoparticles that can be used for various biomedical applications. Given the challenges of non-biodegradability potent inorganic nanoparticles, introduction a ROS-responsive cleavable hierarchical supra-nanostructure provides an exciting opportunity ROS...