4-Amino-6-methyl- 1,2,4-triazine-3(2H)-thione-5-0ne (1) was condensed with propargyl bromidein the presence of sodium rnethoxide to afford 3-propargylmercapto- 4-arnino-6-rnethyl-1,2,4-triazin-5-one(2) . Transformation of the latter to 8-dihydro- 3-methyl-7-methylene-4-oxo-6H-[1,2,4]TRIAZINO [3,4-b] [1,3,4] thiadiazine (3) was performed under the condition of palladium (II) salt. Ring closu...

Treatment of 4-heptafluoroisopropyl-2-methoxy-3,5,6-trifluropyridine (4 ) with aqueous ammonia in THF gave 2-amino-3,5-difluoro-4-heptafluoroisopropyl- 6-methoxy pyridine (5) in 7 1% yield. Chlorination of this amine with 'ButOCl at -16°C gave an unstable product, namely 2-dichloroarnino-3,5- difluoro-4-heptafluoroisopropyl-6-methoxy pyridine (6). Iodine-catalysed rearrangement of this dic...

A novel propargylic electrophile-induced tandem intermolecular addition-semipinacol rearrangement was developed efficiently under mild conditions. Various allylic silylether substrates as well as Co-complexed propargylic species were applicable to this protocol and gave a series of synthetically useful β-propargyl spirocyclic ketones in moderate to good yields. Its synthetic application was als...

Aspergillus flavus was isolated from the soil field cultivated with wheat crop (Triticum astevium L.), which treated Topik EC 100 (Clodinafop-propargyl) herbicide in Al-Fuhud city, southeast of Thi-Qar Governorate-Iraq. samples were collected at a depth (0-15) cm for period 17 weeks, and fungus by dilution method, pH, electrical conductivity, organic matter texture measured. results showed that...

An asymmetric Lewis acid-mediated [2,3]-sigmatropic rearrangement of allylic amines has been developed, affording the corresponding homoallylic amines in good yield and excellent enantioselectivities. The rearrangement proceeds by complexation of the chiral Lewis acid to the amine followed by deprotonation and rearrangement.

4-amino-6-methyl- 1,2,4-triazine-3(2h)-thione-5-0ne (1) was condensed with propargyl bromidein the presence of sodium rnethoxide to afford 3-propargylmercapto- 4-arnino-6-rnethyl-1,2,4-triazin-5-one(2) . transformation of the latter to 8-dihydro- 3-methyl-7-methylene-4-oxo-6h-[1,2,4]triazino [3,4-b] [1,3,4] thiadiazine (3) was performed under the condition of palladium (ii) salt. ring closure o...

Herein we describe the microwave-assisted imidazolecatalyzed transformation of propargyl vinyl ethers (PVEs) into multisubstituted salicylaldehyde motives. The reaction is instrumentally simple, scalable and tolerates a diverse grade of substitution at the propargylic position of the staring PVE. The generated salicylaldehyde motives incorporate a broad range of topologies, spanning from simple...

Crystals of the title salt, C(17)H(28)NO(3) (+)·C(4)H(3)O(4) (-), were obtained by reacting parthenolide with dimethyl-amine followed by conversion of the amine adduct into a water-soluble fumarate salt. Subsequent crystallization of the fumarate salt from water afforded colorless ortho-rhom-bic crystals. The amine addition is highly stereospecific yielding exclusively a single diastereomer wit...