OBJECTIVES To compare outcomes from accelerated alteplase (recombinant tissue plasminogen activator, t-PA) and streptokinase use in acute myocardial infarction. METHODS Review of available studies identified by Medline and other literature searches that met the criteria of being a prospective, randomised clinical trial enrolling over 1000 patients with acute myocardial infarction. The studies...

background contamination of therapeutic recombinant proteins with residual host cell dna must be controlled under the regulatory standards. objectives the current study established a new rapid, sensitive real time polymerase chain reaction (pcr) approach to measure the reliably of the residual escherichia coli (e. coli) host cell genomic dna in the recombinant streptokinase and alfa interferon ...

rt-PA Recombinant tissue plasminogen activator SK Streptokinase UK Urokinase Pro-UK Prourokinase TNK Tenecteplase MCA Middle cerebral artery IU International units ICH Intracerebral hemorrhage PET Positron emission tomography IV Intravenous IA Intra-arterial d: Days Chapter 2 The March of Thrombolytic Therapy for Acute Ischemic Stroke to Clinical Trials: Pre-clinical Thrombolysis and Adjuncts t...

ALI = acute limb ischemia, APSAC = antistreplase, MTD = mechanical thromboembolectomy device, PAT = percutaneous aspiration thromboembolectomy, pro-UK = prourokinase, RPA = reteplase, r-UK = recombinant urokinase, SK = streptokinase, STILE = Surgery versus Thrombolysis for Ischemia of the Lower Extremity [study], tPA = tissue plasminogen activator, TOPAS = Thrombolysis or Peripheral Arterial Su...

We present a version of the RSK correspondence based on Pitman transform and geometric considerations. This unifies ordinary RSK, dual continuous RSK. show that this is both bijection an isometry, two crucial properties for taking limits last passage percolation models. use bijective property to give non-computational proof maps Bernoulli walks nonintersecting walks.

The RSK (90 kDa ribosomal S6 kinase) family comprises a group of highly related serine/threonine kinases that regulate diverse cellular processes, including cell growth, proliferation, survival and motility. This family includes four vertebrate isoforms (RSK1, RSK2, RSK3 and RSK4), and single family member orthologues are also present in Drosophila and Caenorhabditis elegans. The RSK isoforms a...

Prostate cancer is one of the leading causes death among men worldwide; Some data suggest that ribosomal S6 p90 kinase (RSK 1-4), which belongs to group highly conserved Ser/Thr kinases, has been related an increase in prostate levels. For this reason, aim study was evaluate theoretical interaction some quinolone derivatives (compounds 1-19) with RSK-4 using 6rv2 protein and RSK-14 inhibitor (L...