BACKGROUND Severe malaria is a medical emergency associated with high mortality. Adequate treatment requires initial parenteral therapy for fast parasite clearance followed by longer acting oral antimalarial drugs for cure and prevention of recrudescence. METHODS In a randomized controlled clinical trial, we evaluated the 42-day parasitological outcomes of severe malaria treatment with intrav...

ndemic transmissible gastroenteritis (TGE) is defined as the persistence of the TGE virus (TGEV) and disease in a herd. Endemic infection is a common sequel to a primary outbreak in herds of more than 300 sows.1 In these herds, the main clinical findings are diarrhea, primarily in suckling piglets (from 6 days old to about 2 weeks after weaning); diarrhea among recently weaned pigs; and discret...

In seasonally breeding mammals, vernal reproductive development is not directly triggered by increases in day length, rather, an endogenous program of photorefractoriness to short winter days initiates spontaneous development in advance of spring. The transition to the reproductive phenotype is energetically demanding. How food availability in late winter and early spring impacts the onset and ...

The gonads of hamsters maintained in short photoperiods first undergo regression and then spontaneous recrudescence. The latter is indicative of refractoriness of the neuroendocrine axis to short day lengths. We tested the hypothesis that the absence of long-day stimulation contributes to the development of refractoriness to short photoperiods. Male Syrian hamsters were maintained for 26 weeks ...

Plus de mille « leaders sociaux » ont ete assassine.e.s depuis la signature l’Accord Paix entre guerilla des FARC et l’Etat colombien en novembre 2016. Ces chiffres illustrent les failles du regime national international protection ces activistes defenseur.euses droits humains au niveau local, dans un contexte recrudescence violence Colombie stigmatisation continue acteurs.rices implique.e.s sa...

We report a case of a Nepalese who developed a recrudescence of malignant falciparum malaria whilst taking systemic corticosteroids. The malaria was resistant to chloroquine at the RI level, the first such case reported from BMH Dharan.

The author discusses here the efforts made to revive Ayurveda in the twentieth century by the protagonists of Ayurveda during the national movement and appraises how far political support and State patronage did good for the recrudescence of Ayurveda.

Dexamethasone was given to mice infected with Toxoplasma gondii to provide a model of recrudescence of infection in immunocompromised patients and to permit investigation of the interaction between parasite and host.

The trisubstituted pyrrole 4-[2-(4-fluorophenyl)-5-(1-methylpiperidine-4-yl)-1H-pyrrol-3-yl]pyridine (compound 1) is a potent inhibitor of cyclic GMP-dependent protein kinases from Apicomplexan protozoa and displays cytostatic activity against Toxoplasma gondii in vitro. Compound 1 has now been evaluated against T. gondii infections in the mouse and appeared to protect the animals when given in...

We have investigated the immunological basis of pregnancy-related Plasmodium berghei recrudescence in immune mice with substantial preexisting immunity. Specifically, we examined the relevance of this experimental model to the study of pregnancy-associated malaria (PAM) caused by P. falciparum in women with substantial preexisting protective immunity. We used mice with immunity induced prior to...