Local drug delivery has received much recognition in recent years, yet it is still unpredictable how drug efficacy depends on physicochemical properties and delivery kinetics. The purpose of the current study is to provide a useful mathematical model for drug release from a drug delivery device and consecutive drug transport in biological tissue, thereby aiding the development of new therapeuti...

Experimental data on the kinetics of propane hydrate dissociation at 0.1 MPa and different external temperatures were obtained. A two-stage mechanism of hydrate dissociation was observed visually. In the first stage hydrate dissociated into metastable water and gas. During the second stage the metastable water crystallized into ice. The release of metastable water during hydrate dissociation an...

A physically-based two-site mean field model has been developed to describe the microstructural evolution due to recrystallization during and after deformation. The model has been applied to predict the recrystallized fraction, recrystallized grain size, and flow stress of 304L austenitic stainless steel during discontinuous dynamic recrystallization (DDRX), post-dynamic recrystallization (PDRX...