OBJECTIVE To present a structured approach for an outpatient consultation of a child with recurrent mouth ulcers. METHOD Review of literature and description of approach followed in our unit. CONCLUSIONS The literature emphasises the need to consider local and systemic causes for oral ulceration in a child. Focused history and examination are key in establishing the cause and in order to en...

The possible involvement of Toll-like receptor (TLR) genome DNA in the prolongation and relapse of inflammatory intestinal diseases and alcoholic hepatic diseases has been reported. In this study, we examined the relationship of mutations of the TLR 2, 4, 6 and 9 genomic DNA to recurrent or intractable gastritis or gastric ulcers. The subjects were 32 patients, including 6 with H. pylori (Hp)po...

A 53 year-old male diabetic presented with a month-old, painful ulcer with necrotic margins over the right thigh. Wound debridement was done twice and the ulcer showed recurrent growth of a white, cottony filamentous structure. Cutaneous mucormycosis was suspected and confirmed by histopathology and a culture isolate of Apophysomyces elegans . The patient was treated with liposomal amphotericin...

A 67-year-old woman with a 15-year history of intestinal scleroderma presented with recurrent melena. Upper endoscopies revealed a healing, non-bleeding, large gastric ulcer. After the third bleed, angiography demonstrated bleeding from a splenic artery pseudoaneurysm adjacent to the gastric ulcer. Scleroderma patients are at risk of bleeding from esophagitis or gastric arteriovenous malformati...

Aim: The study aimed to evaluate the association between quality of life and wound severity in patients with recurrent diabetic foot ulcers (DFUs). Design: A cross-sectional study. Methods: total sample comprised 86 DFU patients. Diabetic Foot Ulcer Scale – Short Form scale was used to collect data, Wagner grading assess severity. Statistical analyses were conducted using Mann-Whitney...

1.0 Introduction 2.0 History 3.0 Helicobacter pylori 3.1 Epidemiology 3.11 The African Enigma 3.2 Bacteriology/Pathogenesis 3.3 Diagnosis 3.4 Disease States 3.41 Gastric Cancer 3.42 MALT Lymphoma 3.43 Non-ulcer dyspepsia 3.44 GERD 4.0 Forms of Peptic Ulcer Disease 4.1 DU 4.2 GU 4.3 ZE syndrome 4.4 NSAIDS 4.5 Neither H. pylori nor NSAID 4.6 Children 5.0 Management of Peptic Ulcer Disease 5.1 Era...

Measurements were made of the amounts of histamine extracted from patients with peptic ulcer disease and control subjects suffering from various gastrointestinal diseases. Patients with duodenal ulcer, gastric ulcer, or recurrent duodenal ulcer after proximal gastric vagotomy often had less gastric mucosal histamine than did normal controls. Cimetidine therapy increased the amounts of the hista...

BACKGROUND Use of proton-pump inhibitors in the management of peptic ulcer bleeding is controversial because discrepant results have been reported in different ethnic groups. OBJECTIVE To determine whether intravenous esomeprazole prevents recurrent peptic ulcer bleeding better than placebo in a multiethnic patient sample. DESIGN Randomized trial conducted between October 2005 and December ...

The results of vagotomy and simple drainage for recurrent benign lesser curve gastric ulcer are recorded. Seventy-two consecutive cases were treated from 1962 to 1965. The follow-up is therefore from five to eight years. In only two cases did the ulcer fail to heal and remain healed. Four years after operation both these had persistent ulceration and persistent gastric retention. Both have appa...