reduced intensity conditioning

Bipin N Savani Myriam Labopin Didier Blaise Dietger Niederwieser Fabio Ciceri Arnold Ganser Renate Arnold Boris Afanasyev Stephane Vigouroux Noel Milpied Michael Hallek Jan J Cornelissen Rainer Schwerdtfeger Emmanuelle Polge Frédéric Baron Jordi Esteve Norbert C Gorin Christoph Schmid Sebastian Giebel Mohamad Mohty Arnon Nagler

Increasing numbers of patients are receiving reduced intensity conditioning regimen allogeneic hematopoietic stem cell transplantation. We hypothesized that the use of bone marrow graft might decrease the risk of graft-versus-host disease compared to peripheral blood after reduced intensity conditioning regimens without compromising graft-versus-leukemia effects. Patients who underwent reduced ...

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Factors predicting long-term survival after T-cell depleted reduced intensity allogeneic stem cell transplantation for acute myeloid leukemia.

Journal: :Haematologica 2010

Charles Craddock Sandeep Nagra Andrew Peniket Cassandra Brookes Laura Buckley Emmanouil Nikolousis Nick Duncan Sudhir Tauro John Yin Effie Liakopoulou Panos Kottaridis John Snowden Donald Milligan Gordon Cook Eleni Tholouli Tim Littlewood Karl Peggs Paresh Vyas Fiona Clark Mark Cook Stephen Mackinnon Nigel Russell

BACKGROUND Reduced intensity conditioning regimens permit the delivery of a potentially curative graft-versus-leukemia effect in older patients with acute myeloid leukemia. Although T-cell depletion is increasingly used to reduce the risk of graft-versus-host disease its impact on the graft-versus-leukemia effect and long-term outcome post-transplant is unknown. DESIGN AND METHODS We have cha...

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