The main aim of the study is to evaluate efficacy and safety profile Ocrelizumab (OCR), Rituximab (RTX), Cladribine (CLA), employed as Natalizumab (NTZ) exit-strategies in Relapsing-Remitting Multiple Sclerosis (RRMS) patients at high-risk for progressive multifocal leukoencephalopathy (PML).

BACKGROUND There are few treatment options for patients with secondary progressive and worsening relapsing-remitting multiple sclerosis. Mitoxantrone is an antineoplastic drug, recently approved for treatment of multiple sclerosis. Mitoxantrone is, however, associated with dose-related cardiotoxicity, which limits its use. OBJECTIVE To investigate the possible cardiotoxicity of mitoxantrone i...

Conduction along the optic nerve is often slowed in multiple sclerosis (MS). This is typically assessed by measuring the latency of the P100 component of the Visual Evoked Potential (VEP) using electroencephalography. The Visual Evoked Spread Spectrum Analysis (VESPA) method, which involves modulating the contrast of a continuous visual stimulus over time, can produce a visually evoked response...

Background & Aims: Substance abuse may have different effects on multiple sclerosis. Till now, studies on substance abuse and its correlation with psychopathology, type and severity of multiple sclerosis are limited. We conducted this study to evaluate the psychopathology of patients with multiple sclerosis with and without substance abuse. Methods: In this case-control, cross-sectional study p...

BACKGROUND Sympathovagal imbalance has been associated with poor prognosis in chronic diseases, but there is conflicting evidence in multiple sclerosis. OBJECTIVES The objective of this study was to investigate the autonomic nervous system dysfunction correlation with inflammation and progression in multiple sclerosis. METHODS Heart rate variability was analysed in 120 multiple sclerosis pa...

Background: Neurofibromatosis type I(NF1) is a neurocutaneous autosomal dominant disorder that has variable skin and neurological manifestation Multiple sclerosis (MS) not among these sequalae of Neurofibromatosis. Only 26 cases have been reported worldwide to the combination two diseases, none them from Saudi Arabia.We are presenting young lady who was diagnosed Sclerosis, Relapsing remitting ...