The ability of the M2 muscarinic receptor to inhibit the relaxant effects of forskolin and isoproterenol was investigated in bovine trachea. In most experiments, we measured contractile responses to oxotremorine-M in smooth muscle isolated from bovine trachea in which a majority of M3 receptors were inactivated by treatment with N-(2-chloroethyl)-4-piperidinyl diphenylacetate. In the presence o...

objective: asafoetida (ferula assa-foetida) is known as a valuable remedy for whooping cough, pneumonia, bronchitis in children and asthma treatment in folk medicine. in the present study the relaxant effects of the asafoetida on tracheal smooth muscle of guinea pigs and its probable mechanism(s) were examined. materials and methods: the relaxant effects of three cumulative concentrations of th...

Temporomandibulardisordercharacterizes a varied group of pathologies affecting temporomandibularjoints, masticatory muscles, or both.The treatment temporomandibular disorders is major challenge because its causes and structures involved also the functioning one joint always dependent on other. Transcutaneous electric nerve stimulation non-pharmacological method pain control recently it gaining ...

Hayatin methiodide has been used as a muscle relaxant during surgery in 100 patients. This drug provided adequate relaxation for endotracheal intubation and surgery. It appeared to be about one-third as potent as tubocurarine. The duration of both these drugs was of equal magnitude in equipotent doses. The neuromuscular block produced by this drug could be completely reversed by neostigmine. It...

Objective: Asafoetida (Ferula assa-foetida) is known as a valuable remedy for whooping cough, pneumonia, bronchitis in children and asthma treatment in folk medicine. In the present study the relaxant effects of the asafoetida on tracheal smooth muscle of guinea pigs and its probable mechanism(s) were examined. Materials and Methods: The relaxant effects of three cumulative concentrations of t...

Saffron, Crocus sativus L. (C. sativus) is rich in carotenoids and used in traditional medicine for treatment of various conditions such as coughs, stomach disorders, amenorrhea, asthma and cardiovascular disorders. These therapeutic effects of the plant are suggested to be due to its relaxant effect on smooth muscles. The effect of C. sativus and its constituents on different smooth muscles an...

Nigella sativa (N. sativa) is a spice plant which has been traditionally used for culinary and medicinal purposes. Different therapeutic properties including the beneficial effects on asthma and dyspnea, digestive and gynecology disorders have been described for the seeds of N. sativa. There is evidence of the relaxant effects of this plant and some of its constituents on different types of smo...

The possible role of endothelium in the vascular responses to vasodilator drugs was studied in relation to experimental hypertension. Short ring segments of the thoracic aorta and femoral artery were removed from spontaneously hypertensive rats (SHR) and normotensive WistarKyoto (WKY) rats. They were rubbed on the intimal surface to destruct endothelial cells or unrubbed, and bathed in Krebs-bi...

Serum potassium changes with direct E.C.T. and with modified E.C.T., given under three anaesthetic (thiopentone, diazepam and propanidid) and relaxant (suxamethonium) combinations were studied in 25 patients. Ten patients each, undergoing minor surgical procedures, acted as controls for these three combinations. Modified E.C.T. caused a rise in scram potassium, which, being highest at 3 minutes...