BACKGROUND Some microRNAs (miRNAs) are abnormally expressed in cancer and contribute to tumorigenesis. In the present study, we investigated the role of miR-506 in clear cell renal cell carcinoma (ccRCC). METHODS miR-506 expression was detected in renal cancer cell lines 786-O, ACHN, Caki-1, and Caki-2 and ccRCC specimens by quantitative real-time-PCR. We assessed the association of miR-506 e...

Alcohol consumption has been associated with a decreased risk for renal cell cancer in several studies. We investigated whether alcohol is associated with (epi)genetic changes of the von Hippel-Lindau (VHL) gene in renal cell cancer. The Netherlands Cohort Study (NLCS) on Diet and Cancer started in 1986 (n = 120,852) and uses the case-cohort method. After 11.3 years of follow-up, 314 renal cell...

OBJECTIVE Type 2 diabetes is associated with increased risks of several types of cancer; however, its relationship to renal cell cancer remains unclear. RESEARCH DESIGN AND METHODS A total of 118,177 women aged 30 to 55 years at baseline (1976) were followed up through 2008 in the Nurses' Health Study. Self-reports of physician-diagnosed diabetes were collected at baseline and updated biennia...

(8). Incidental renal masses tend to be smaller than symptomatic masses (9), but they are not harmless. In a study of nearly 4,000 patients with incidental renal tumors, 14.4% died of cancer over an average 4-year follow-up, despite treatment (10). Most solid renal masses are presumed to be malignant and excised. There is therefore relatively little data on the natural history of untreated mass...

Alias Multiple cutaneous and uterine leiomyomatosis (MCUL) Hereditary leiomyomatosis and renal cell cancer (HLRCC) Note Multiple cutaneous leiomyomatosis (MCUL) is characterized by multiple leiomyomas of the skin and uterus. When associated with renal cell cancer, this syndrome is referred to as hereditary leiomyomatosis and renal cell cancer (HLRCC). Inheritance Autosomal dominant with incompl...

CONTEXT Clinical surveys have revealed that incidental detection of renal cell carcinoma is rising because of increased use of imaging procedures. OBJECTIVE To examine incidence, mortality, and survival trends of renal cell and renal pelvis cancers by age, sex, race, and tumor stage at diagnosis. DESIGN Calculation of age-adjusted incidence and mortality rates, along with 5-year relative su...

We present herein the case of a patient with solitary metachronous contralateral adrenal metastasis from renal cell cancer. The patient had undergone left radical nephrectomy and adrenalectomy for localized renal cancer 7 years previously. Laparoscopic transperitoneal right adrenalectomy was performed. The postoperative period was uneventful. Histology showed right adrenal metastasis from renal...

Advanced renal cancer is an incurable malignancy in need of novel therapeutic avenues. We have generated interferon γ (IFNγ)-based fusion antibodies (immunocytokines) that target CD70, a putative biomarker of renal cancer. These immunocytokines efficiently labeled renal cancer cells, and, when combined with the proteasome inhibitor bortezomib, killed them by activating a RIP1-dependent necrotic...

Malignant tumors of the kidney account for about 1.9% of total world cancers, with about 150,000 new cases annually. Renal parenchyma (renal cell) cancer represents around 80% of this total and nearly all of these cases are adenocarcinomas. As a whole, it is difficult to obtain clear descriptive patterns of incidence and mortality from renal cell cancer, since population data from different reg...

As morbidity and mortality from graft dysfunction and failure after kidney transplantation have declined, transplant-related malignancies have become one of the most significant sources of posttransplant complications. Currently, cancer is a major factor limiting the life expectancy of kidney transplant patients, and cancer management is now a crucial component of their medical care. This paper...