The cover image is based on the Review Article Interconnection between cardiovascular, renal and metabolic disorders: A narrative review with a focus Japan by Takashi Kadowaki MD et al., https://doi.org/10.1111/dom.14829.

Sir, Cutaneous manifestations are frequently found in patients with chronic renal failure. They can be classified as specific disorders (e.g. perforating disorders, metastatic calcification, bullous dermatosis) or non-specific disorders (e.g. skin colour changes, pruritus, elastosis, equimosis, xerosis, uraemic frost, half and half nails). We report here an unusual association between an acanth...

Background Few results have shown that renal parenchymal echogenicity increases in pediatric patients with no concurrent renal diseases. This study aimed to investigate the relation between non-renal diseases and renal cortical echogenicity in children with acute abdominal pain. Materials and Methods  This cross- sectional study was conducted among 100 children referred to Amirkola Children’s ...

This review summarizes the clinical evidence and practical details for the use of plasmapheresis and other apheresis modalities for each indication in nephrology. Updated information on the molecular biology and immunology of each renal disease is discussed in relation to the rationale for apheresis therapy and its place amid other available treatments. Autoantibody-mediated diseases, such as a...

The renal tubule plays an important role in fluid and electrolyte homeostasis. Renal tubular disorders may affect multiple ( e.g., Fanconi syndrome) or specific (e.g., nephrogenic diabetes insipidus, renal glucosuria) tubular functions. Most conditions are primary and monogenic but occasionally are secondary to other disorders (focal segmental glomerulosclerosis, cystinosis, Lowe syndrome). Tub...

The ability of the kidneys to excrete a concentrated urine is impaired together with other renal functions whenever the kidneys are progressively scarred and the amount of functioning renal parenchyma is diminished. Concentrating capacity and glomerular filtration rate are therefore reduced roughly in parallel in many common diseases which cause widespread scarring of the kidneys. The present d...

Introduction Research into the aetiology of calculus disease has failed to reveal the fundamental cause of stone formation, but it is apparent that various factors predispose to their development. Renal calculi are likely to occur in most diseases in which there is an increased urinary excretion of crystalloid stone-forming substances. Calcium phosphate and oxalate stones are particularly liabl...

background and aims: methotrexate (mtx), a folic acid antagonist, is widely used as a treatment for malignancies as well as in the treatment of various inflammatory and autoimmune disorders. nephrotoxicity is an important side-effect of this drug. prevention and treatment of mtx-induced renal dysfunction are essential to prevent potentially life-threatening mtx-associated toxicities, present st...