Background & Aims: Liver ischemia-reperfusion (IR) is one of the common consequences of liver surgery, especially during liver transplantation which results in organ dysfunction. Acute hepatic injury causes systematic inflammatory responses which may finally lead to functional disturbances in remote organs such as heart, lungs and kidneys. In this study, the effects of a potent inhibitor of inf...

background: the aim of this study was to investigate the protective effects of crocin against tissue damages and leukocyte infiltration induced by renal ischemia/reperfusion. methods: in this experimental study, 35 male wister rats weighing 250-300 g were randomly divided into 5 groups; 1. operated controls, but no vessel occlusion was considered and passed during equivalent reperfusion period ...

objective(s)ischemia-reperfusion injury (iri) is a leading cause of kidney transplantation failure, and ischemic-preconditioning (ipc) is a protective method against the iri. in the present study, the defensive effect of ipc on rats’ kidney was investigated and more importantly the differences between two genders were appraised.materials and methodsthirty two wistar rats were randomly allocated...

background: previous studies have shown increases in endothelin (et) concentration of plasma and renal tissues in acute renal failure (arf).  et has a potent vasoconstrictor effect, through binding with its et a receptors, and may play some roles in renal hemodynamic dysfunction in arf. objective: to examine the beneficial effect of a selective et a -receptor antagonist on renal dysfunction and...

Introduction: Acute kidney injury (AKI) has been known as a complex clinical complication in diabetic patients. The main cause of AKI is ischemia/reperfusion injury (IRI). This study was designed to investigate the protective effects of GABA on renal IRI in hyperglycemic female and male rats. Methods: Sixty STZ induced diabetic male and female Wistar rats were categorized in 10 groups (5 fem...

OBJECTIVE To study the effect of ischemia preconditioning (IP) on renal ischemia/reperfusion (I/R)-associated functional injury and expression of renal adhesion molecules in rats. MATERIALS AND METHODS The ischemia preconditioning plan adopted in this experiment involved renal warm ischemia for 6 min. and blood flow for 4 min., repeated four times. The Wistar rat kidneys used for warm ischemi...

The effect of gallic acid on oxidative stress parameters and hippocampal cell density in ischemia-renal reperfusion model

Tolerance of the human kidney to ischemia is controversial. Here, we prospectively studied the renal response to clamp ischemia and reperfusion in humans, including changes in putative biomarkers of AKI. We performed renal biopsies before, during, and after surgically induced renal clamp ischemia in 40 patients undergoing partial nephrectomy. Ischemia duration was >30 minutes in 82.5% of patien...

background: acute kidney injury (aki) has been recognized as one of the most complex clinical complications in modern medicine, and ischemia/reperfusion (i/r) injury is well-known as a main reason of aki. in addition, aki leads to important systemic consequences such as acute lung injury. this study was designed to investigate the role of erythropoietin (epo) on kidney function makers and tissu...

background: renal ischemia reperfusion injury may occur in a variety of clinical situations, following a transient drop in total or regional blood flow to the kidney. this study was performed to investigate the protective effects of different antioxidants such as vitamin c, vitamin e, hydrocortisone and combination of these agents against experimental renal ischemia-reperfusion injury. method:...