Introduction. Hepatitis C virus (HCV) infection is an independent risk factor for renal transplantation (RTx). Immunosuppression minimization can render better quality of life to these patients. Methods. We analyzed 132 HCV-positive RTx patients (group A) transplanted under tolerance induction protocol (TIP) and compared them with 79 controls (group B) transplanted using standard triple drugs. ...

BACKGROUND Tissue transglutaminase (TG2), a cross-linking enzyme, modulates deposition of extracellular matrix protein in renal fibrosis. This study aimed to examine TG2 and its cross-link product ε(γ-glutamyl)-lysine in the Fisher-Lewis rat renal transplantation (RTx) model of chronic allograft nephropathy (CAN). MATERIALS AND METHODS Left renal grafts from male Fisher and Lewis were transpl...

background: monitoring of phenotypic characteristics of t-lymphocytes in peripheral blood is commonly performed to give the clinical parameters in the management of kidney transplant recipients.   objective: to predict rejection in renal transplantation by immune parameters. methods: 16 non-diabetic kidney transplant candidates (4 females and 12 males, age = 20-65 yr, first time transplant) wer...

background and objective: cystinosis is a rare inherited disease that leads to renal failure. fanconi syndrome is the major renal involvement in cystinosis patients. renal transplantation is the treatment of choice in cystinosis children with end-stage renal disease (esrd).  the study aimed to assess the outcome of renal transplantation in iranian children with cystinosis. methods: this retrosp...

BACKGROUND Deceased donor organ shortage has made living donors (LD) major source for renal transplantation (RTx) in India. Spouses represent an important source of allograft. We carried out a retrospective study of spousal RTx vs. other LDRTx to compare long-term results. METHODS This retrospective single-center study was undertaken to evaluate demographic, patient survival, graft survival, ...

BACKGROUND A standard fixed dose of 2 g/day of mycophenolate mofetil (MMF), irrespective of total body weight (TBW), is recommended when used in combination with cyclosporine and corticosteroids in renal transplantation. METHODS To determine the optimal MMF dose in a population with wide variation in TBW, steady-state pharmacokinetics of mycophenolic acid (MPA) was performed in 53 Asian (Chin...

Renal transplant (RTx) recipients are at a high risk of infection caused by commensal bacteria. Apart from immunodeficiency resulting from the use of immunosuppression, RTx patients often suffer from various urological malformations, increasing susceptibility to infections. In the early phase after renal transplantation, when patients are exposed to the most intense immunosuppression and entero...

background: cytomegalovirus (cmv) disease is an important cause of death and possibly transplant rejection in kidney transplant (kt) patients. this study was conducted to investigate the incidence and risk factors of cmv disease in kidney transplant patients. methods: all end-stage renal disease (esrd) patients who underwent kidney transplantation during 1998-2014 and their donors were assessed...

PURPOSE Despite new treatment strategies, anemia remains the most prevalent complication in patients with end-stage renal disease (ESRD). We investigated whether 25-hydroxyvitamin D [25(OH)D3] deficiency was associated with anemia in ESRD patients. MATERIALS AND METHODS We reviewed the medical records of 410 ESRD patients who had undergone renal transplantation (RTx) at Yonsei University Heal...

Thromboxane (TX) plays important roles in control of renal hemodynamics and water and electrolyte metabolism, and is involved in the pathophysiology of many renal diseases. The aim of the present study is to isolate a rat kidney cDNA encoding functional TX receptor, and to reveal its intrarenal expression localization. A clone (rTXR2) was isolated from a rat kidney cDNA library by a homology sc...