The effects of long-term reserpine therapy (1) on cardiac output during rest and induced atrial tachycardia and (2) on atrioventricular (A-V) conduction were examined in a group of eight men with previously untreated essential hypertension. The patients were studied before and after 20 to 205 days of reserpine therapy. All studies were performed in the cardiopulmonary laboratory with the patien...

Synthesis of collagen in the vasculature and other tissues of normotensive rats is markedly reduced by reserpine. Hypophysectomy produces similar effects. The effects of reserpine on collagen biosynthesis may be mediated through the hypothalamus.

Sleep is an important physiological state, but its function and regulation remain elusive. In Drosophila melanogaster, a useful model organism for studying sleep, forward genetic screens have identified important sleep-modulating genes and pathways; however, the results of such screens may be limited by developmental abnormalities or lethality associated with mutation of certain genes. To circu...

BACKGROUND The antihypertensive reserpine is an indole alkaloid from Rauwolfia serpentina and exerts also profound activity against cancer cells in vitro and in vivo. The present investigation was undertaken to investigate possible modes of action to explain its activity toward drug-resistant tumor cells. MATERIAL AND METHODS Sensitive and drug-resistant tumor cell lines overexpressing P-glyc...

Nagarmotha roots were obtained from a local dealer of Ayurvedic medicines, identified and a suspension containing 80 mgiml of the drug '\as prepared in ion free distilled water using gum acasia as suspending agent. Healtr.y pigeons weighing between 200-300 g were divided into four groups of 10 each. They were fed with grain (Jwar) in the morning and the experiments were performed at II a.m. Gro...

Purpose: To develop a simple, rapid and improved colorimetric method for the assay of reserpine in tablets Method: The method is based on the aromatic ring coupling of reserpine with 4-carboxyl-2,6dinitrobenzene diazonium ion with the consequent formation of an azo adduct. Optimization of reaction conditions and validation were carried out and the method applied to assay of reserpine in tablets...

Adult Syrian hamsters were given a subcutaneous injection of reserpine 3 days before an intraperitoneal injection of (3)H-3,4 dihydroxyphenylalanine or (3)H-5, hydroxytryptophan and the carotid bodies were subsequently prepared for electron microscopic radioautography. Other Syrian hamsters were given a subcutaneous injection of reserpine and the carotid bodies were subjected to a sensitive cyt...

Recent reports on the efficacy of pharmacological management in reducing mortality associated with mild hypertension have enhanced the importance of increasing our knowledge about drug toxicity. The Hypertension Detection and Follow-Up Program (HDFP) provides a convenient setting in which to examine the association reported between reserpine usage and breast cancer. In the intensively treated a...

Individuals are known to differ in their sensitivity to cocaine. Cocaine is known to inhibit the re-uptake of monoamines. The response to cocaine has also been found to depend on monoamines inside reserpine-sensitive storage vesicles. The present study examined the effects of reserpine (1-2 mg/kg) on cocaine-induced behavior (10-15 mg/kg) in Low Responders (LR) and High Responders (HR) to novel...