RNA molecules that can bind to the Rev protein of HIV-1 have been isolated from random sequence nucleic acid pools based on a minimal Rev-binding element (RBE) found within the Rev Responsive Element (RRE). While the selected sequences are related to the wild-type element, they also contain substitutions that allow them to bind Rev up to 10-fold better in vitro. A hypothesized homopurine pairin...

A global reaction route map is generated for Au5 by the anharmonic downward distortion following method in which 5 minima and 14 transition states (TSs) are located. Through vibrational analyses in the 3N - 7 (N = 5) dimensional space orthogonal to the intrinsic reaction coordinate (IRC), along all the IRCs, four IRCs are found to have valley-ridge transition (VRT) points on the way where a pot...

Thirty-four production workers at three chemical plants were tested for acute changes in lung function over the course of their three-day, twelve-hour workshift. Mean percentages of the predicted lung function indices (FVC, FEV, and FEF 25-75) showed a workshift decrement, particularly evident in the evening shift. A workweek effect was shown in that no recovery in mean %FEV1 and %FEF-25-75 was...

which affect 60-80% of residents with dementia. Responsive behaviours are commonly treated with antipsychotic medications, and they compromise well-being of residents as well as staff. Our multidisciplinary team seeks to develop technological solutions to help minimize agitated and aggressive behaviours by creating familiar and appropriate activities that allow residents with dementia opportuni...

This paper discusses the responsive sound installation Reeds. The Melbourne International Festival of the Arts commissioned the Reeds project in 2000, for exhibition on the Ornamental Lake at the Royal Botanic Gardens, Melbourne. It consists of twenty-one large floating sculptures, modeled to represent clusters of river reeds in immaculate man-made plantings. Each reed pod contained a collectio...

The Interprofessional Resource Centre (IRC) was based on an extensive literature search and a provincial consultative process that involved administrators, health care providers, educators, preceptors, and alternative and complementary health care providers from different disciplines. Information from the literature review was synthesized into a logic model that served as a preliminary outline ...

Considerable amount of work has been directed towards the development of optimal glucose-responsive devices for insulin release. Hydrogel-based devices offer a wide range of parameters that can be tuned to obtain easy control of the insulin release properties. Taking advantage of their unique swelling and release properties, we may be able to achieve the desirable steady state and dynamic natur...