Pathophysiology of restless legs syndrome is poorly understood. A role of the thalamus, specifically of its medial portion which is a part of the limbic system, was suggested by functional magnetic resonance imaging and positron emission tomography studies. The aim of this study was to evaluate medial thalamus metabolism and structural integrity in patients with idiopathic restless legs syndrom...

The gene, BTBD9, was recently linked to restless legs syndrome, periodic limb movements and iron status in humans. In a homologous region in mouse, an area containing btbd9 was also identified as being related to iron homeostasis. This finding is important as iron status in brain has been implicated in restless legs syndrome.

Restless Legs Syndrome (RLS) is a sleep-associated movement disorder with sensory and motor components that follows a chronic course. Acute development of RLS has rarely been reported. Our purpose was to raise awareness of the subject by describing a picture of acute RLS in a case of Guillain-Barre syndrome. Citation: Vildan Altunayoglu Cakmak., et al. “Restless Legs Syndrome Presenting As Acut...

Pathophysiology of restless legs syndrome is poorly understood. A role of the thalamus, specifically of its medial portion which is a part of the limbic system, was suggested by functional magnetic resonance imaging and positron emission tomography studies. The aim of this study was to evaluate medial thalamus metabolism and structural integrity in patients with idiopathic restless legs syndrom...

Being of the most frequent causes of insomnia, which in the end leads to chronic fatigue, inadequate performance of daily activities, and serious disruption of quality of living, restless legs syndrome (RLS) is nowadays not only a serious medical problem but a socio-economical one as well. Prevalence of the disorder in general population is estimated at 5 to 15%. Family history is positive in o...

BACKGROUND: The last 20 years witnessed increased medical awareness regarding restless legs syndrome (WillisEkbom disease) among adults and children. However, it remains underdiagnosed and undertreated. Diagnosis relies exclusively on the history described by patients in their own words. Children who cannot adequately describe their symptoms represent a difficulty. To circumvent this, probable ...

Restless legs syndrome (RLS) is characterised by daily dynamic sensorial and motor syndromes. It is a relatively little known syndrome among neurologists as well as psychiatrists. In spite of a growing number of researches on this issue, the problem seems to be underdiagnosed. Because of a subjective character of the symptoms and also their appearance in the evening hours, they are difficult to...

PURPOSE The signs and symptoms, epidemiology, etiology, pathophysiology, diagnosis, pharmacologic and nonpharmacologic treatments, and options and guidelines for the treatment of restless legs syndrome (RLS) are reviewed. SUMMARY RLS was first described in the 17th century and further characterized in 1945. RLS is a common disorder, occurring in about 10% of the population. Patients with RLS ...