After observing that several families with essential tremor (ET) clinically cosegregated with restless legs syndrome (RLS), we prospectively evaluated for the presence of RLS in 100 patients presenting to the Baylor College of Medicine with ET and prospectively examined all patients presenting with RLS for the presence of tremor during the same time frame. Of 100 consecutive ET patients (60 wom...

We report results from three independently conducted studies on the prevalence of cancer in restless legs syndrome (RLS) cases and non RLS cases. Already in 1955 Ekbom observed RLS in patients with subsequently detected cancer. Since then only three case reports and one article assessed the relationship between RLS and cancer patients undergoing chemotherapy. The observed proportion of RLS in t...

BACKGROUND An association between restless legs syndrome and migraine has been reported recently. The clinical correlates and impact of comorbidity of restless legs syndrome (RLS) are not fully described in patients with migraine. OBJECTIVES To investigate the frequency of RLS among different primary headache disorders, and its impact and clinical correlates in migraine patients. METHODS Co...

Objective Restless legs syndrome (RLS) is considered a genetic disease and, following a genome-wide association study conducted in 2007, the mitogen-activated protein kinase 5 (MAP2K5) gene has been regarded as the promising candidate gene for RLS. The present study investigated whether polymorphisms of MAP2K5 are associated with antipsychotics-induced RLS in schizophrenia. Methods We assesse...

Introduction: Restless legs syndrome (RLS) is a neurological sensory-motor disorder that is observed as an unpleasant sensation in the legs, especially when sitting or lying down and at rest. This study aimed to determine the prevalence RLS and its related factors among older adults in Eslamabad-e-Gharb, Kermanshah province, Iran in 2021. Methods: Totally, 240 elderlies entered the study using...

Chronic back pain is one of the most common reasons for missed work and visits to the doctor. This report presents 2 interesting cases of chronic back pain that were effectively relieved by low-dose levodopa. These 2 patients showed no sign of anatomical problem of the spine or relative structures, but the discomforts on the back manifested some characteristics resembling those in restless legs...

Restless legs syndrome (RLS) is a common clinical entity consisting of an uncomfortable sensation in one’s legs and irresistible urge or desire to move them usually occurring in the evening. This syndrome has been sub optimally diagnosed in the past and remains overall misunderstood and under-recognized by many primary health care providers. However, RLS is increasingly recognized to cause sign...

BACKGROUND The occurrence of restless legs syndrome (RLS) in elderly individuals is well known but the incidence and the clinical correlates in these subjects are still unclear. The present study explores the prevalence of and assesses symptoms associated with RLS in an older French population. METHODS The study sample for this study comprised 318 subjects (219 women and 99 men), aged 68.6 +/...

BACKGROUND Restless Legs Syndrome (RLS) is a common neurological movement disorder characterized by symptoms that follow a circadian pattern. Night and rotating shift work schedules exert adverse effects on functions of the human body by disturbing circadian rhythms, and they are known to cause sleep disturbances and insomnia. In this paper, we investigate the possible association between shift...

Ropinirole is a non-ergoline dopamine agonist that exhibits a high affinity for D(2) and D(3) receptors but little or no affinity for D(1)-like and non-dopaminergic receptors. Symptoms of restless legs syndrome (RLS) [measured using the International Restless Legs scale and Clinical Global Impression-Global Improvement Scale scores] significantly improved with ropinirole compared with placebo i...