the transcriptional factor oct4 regulates pluripotency of stem cells and has an important role during oocyte growth. whereas, its role has remained ambiguous in ovarian tissue during reproductive cycle. therefore, this study was aimed to investigate the expression patterns of oct4 in mouse ovaries during the normal estrous cycle. adult national medical research institute mice were classified as...

Background: Colorectal Cancer (CRC) is the most common malignant gastrointestinal cancer. stem cells (CSCs) are major cause of cancer recurrence and drug resistance. Silibinin, as an herbal compound, has anticancer properties. Objectives: The present study aimed to evaluate antiproliferative effects silibinin on HT29 stem-like (spheroids). Methods: In this study, apoptotic properties Silibinin ...

background and aims: immunohistochemical tests are one of the most important tests, which are under study to determine the prognosis of the cancers such as transitional cell carcinoma. by the time, flexible cystoscopy and urine cytology are the routine tests for following up the patients with transitional cell carcinoma, which are both operator dependent. on the other hand, cystoscopy is an inv...

background and aims. the aim of this study was to evaluate the effect of different etching times on enamel color stability after immediate versus delayed exposure to colored artificial saliva (cas). materials and methods. human first premolars were divided into five groups of twenty. a colorimeter was used according to the cie system on the mid-buccal and mid-lingual surfaces to evaluate initia...

Infectious bursal disease (IBD) is an immunosuppressive, acute and highly contagious illness of growing-poultry stock infected with infectious bursal disease virus (IBDV). It is common in Pakistan, causing potential economic losses throughout the year. The objective of the study is to propose a rapid, sensitive and specific diagnostic tool, and compare it with existing commonly used reverse tra...

Background: Breast cancer is the most common cancer in women, containing approximately one third of all illnesses in women. Assessment of molecular markers is valuable in predicting the outcome of disease and decision making for optimal treatment. The purpose of this study was to determine the relationship between estrogen and progesterone receptors with Her-2, Ki67, P53, and clinicopathologica...

The transcriptional factor OCT4 regulates pluripotency of stem cells and has an important role during oocyte growth. Whereas, its role has remained ambiguous in ovarian tissue during reproductive cycle. Therefore, this study was aimed to investigate the expression patterns of OCT4 in mouse ovaries during the normal estrous cycle. Adult National Medical Research Institute mice were classified as...

Objective(s): The aim of this study was to investigate the effects of mild hypothermia on expression of NF-E2-related factor 2 (Nrf2) and heme-oxygenase-1 (HO-1) of rat cerebral cortex and hippocampus after cardiopulmonary resuscitation and further investigate the possible mechanism of action. Material and Methods:To copy an asphyxia heart arrest model, Sprague Dawley rats were randomly divided...