The interaction between polypeptides and membranes is a fundamental aspect of cell biochemistry. Liposomes have been used in this context as in vitro systems to study such interactions. We present here the case of giant vesicles (GVs), which, due to their size (radius larger than 10 microns), mimic more closely the situation observed in cell membranes and furthermore permit to study protein-mem...

A clinically practical algorithm has been developed for the treatment of liver cancer by the administration of rhenium-188 ((188)Re)-labeled lipiodol via the hepatic artery. This algorithm is based on the "maximum tolerated-activity" paradigm for radionuclide therapy. A small "scout" activity of (188)Re-labeled lipiodol is administered to the patient before the actual therapeutic administration...

There is an urgent need for new antimicrobial therapies to combat drug resistance, new pathogens, and the relative inefficacy of current therapy in compromised hosts. Ionizing radiation can kill microorganisms quickly and efficiently, but this modality has not been exploited as a therapeutic antimicrobial strategy. We have developed methods to target ionizing radiation to a fungal cell by label...

BACKGROUND: Radiosynovectomy is a type of radiotherapy used to relieve pain and inflammation from rheumatoid arthritis. In this study, 188-Rhenium (188Re) colloids were characterized by physical and biological methodologies. This was used to assess which parameters of the kit formulation would be the basis in the development of a more effective radiopharmaceutical for synovectomy. Intraarticula...

complications and TRM? In contrast to the cohort of Bunjes the majority of our patients suffered from Philadelphia chromosome–positive ALL. Several studies demonstrated a high TRM in patients with this disease.2,3 However, this does not explain the high frequency of acute intestinal GvHD. The second obvious difference was the use of unmanipulated grafts or early incremental T-cell add backs. We...

complications and TRM? In contrast to the cohort of Bunjes the majority of our patients suffered from Philadelphia chromosome–positive ALL. Several studies demonstrated a high TRM in patients with this disease.2,3 However, this does not explain the high frequency of acute intestinal GvHD. The second obvious difference was the use of unmanipulated grafts or early incremental T-cell add backs. We...