Rheumatic heart disease (RHD) is the most common cause of acquired in children and young adults. It continues to be prevalent many low- middle-income countries where it causes significant morbidity mortality. Following 2017 Cairo conference “Rheumatic Heart Disease: from Molecules Global Community,” experts 21 formulated an approach for addressing problem RHD: “The Accord on Disease.” The attem...

BACKGROUND The reason why some individuals but not others are susceptible to rheumatic fever and chronic rheumatic heart disease is not understood. Because of the substantial evidence that poverty is an important determinant of the disease and must operate in early life, we have investigated the role of the early environment in an ecological study using 20(th) century mortality as an index of d...

Objective: Review of the literature addressing the rheumatic manifestations of various malignancies as well as of common chemotherapeutic agents. Methods: A literature search was performed to identify key articles regarding the association of rheumatic disease with malignancy. Results: Our review focused on the association of rheumatic disease with malignancy, paraneoplastic syndromes with rheu...

STUDY OBJECTIVE The aim was to determine the prevalence of rheumatic fever and rheumatic heart disease and to initiate a programme of secondary prophylaxis in Sahafa Town, Sudan. DESIGN The study was a prospective case finding survey, carried out by a specially trained team headed by a cardiologist. SETTING The study involved high risk school children (5-15 years of age) from Sahafa Town in...

Rheumatic heart disease, often neglected by media and policy makers, is a major burden in developing countries where it causes most of the cardiovascular morbidity and mortality in young people, leading to about 250,000 deaths per year worldwide. The disease results from an abnormal autoimmune response to a group A streptococcal infection in a genetically susceptible host. Acute rheumatic fever...

BACKGROUND Epidemiologic studies of the prevalence of rheumatic heart disease have used clinical screening with echocardiographic confirmation of suspected cases. We hypothesized that echocardiographic screening of all surveyed children would show a significantly higher prevalence of rheumatic heart disease. METHODS Randomly selected schoolchildren from 6 through 17 years of age in Cambodia a...

Vitiligo is a chronic disease characterized by the dysfunction or destruction of melanocytes with secondary depigmentation. The aim of the present study was to determine the prevalence of vitiligo associated with autoimmune rheumatic diseases. The clinical records from a 10-year database of patients with rheumatic diseases and associated vitiligo was analysed, with one group of patients having ...

The diagnosis of acute rheumatic fever is a clinical challenge and depends on the possibility of the disease being borne in mind. Although the complete eradication of rheumatic fever from the Western world has not been achieved, the disease is often forgotten in the differential diagnosis of a patient with fever and polyarthralgia or arthritis. Rheumatic fever remains an important acquired card...