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Charcot-Marie-Tooth (CMT) disorders are a clinically and genetically heterogeneous group of hereditary motor and sensory neuropathies characterized by muscle weakness and wasting, foot and hand deformities, and electrophysiological changes. The CMT4H subtype is an autosomal recessive demyelinating form of CMT that was recently mapped to a 15.8-Mb region at chromosome 12p11.21-q13.11, in two con...

Some generalizations of Banach's contraction principle, which is a fixed-point theorem for mapping in metric spaces, have developed rapidly recent years. the things that support development generalization are emergence mappings more general than and spaces spaces. The generalized Kannan type one mappings. Furthermore, some b-metric modular bring concept into theorems Kannan-type on been given. ...

Central core disease (CCD) is a human congenital myopathy characterized by fetal hypotonia and proximal muscle weakness that is linked to mutations in the gene encoding the type-1 ryanodine receptor (RyR1). CCD is thought to arise from Ca(2+)-induced damage stemming from mutant RyR1 proteins forming "leaky" sarcoplasmic reticulum (SR) Ca(2+) release channels. A novel mutation in the C-terminal ...

With the new measurements of $X(3872)\ensuremath{\rightarrow}J/\ensuremath{\psi}{\ensuremath{\pi}}^{+}{\ensuremath{\pi}}^{\ensuremath{-}}$ from LHCb Collaboration, in addition to dominant contribution ${\ensuremath{\rho}}^{0}$ meson, we perform a theoretical study on $\ensuremath{\omega}$ meson and $X(3872)\ensuremath{\rightarrow}J/\ensuremath{\psi}{\ensuremath{\pi}}^{+}{\ensuremath{\pi}}^{\ens...

Membrane depolarization is critical to pulmonary arterial (PA) contraction. Both L-type Ca(2+) channels (Ca(L)) and Rho-kinase are important signaling components of this process and mitochondrial and non-mitochondrial generated superoxides can be part of the signaling process. Maturation and long-term hypoxia (LTH) each can modify depolarization-dependent contraction and the role of superoxides...

In the present paper, we introduces the notion of integral type contractive mapping with respect to ordered S-metric space and prove some coupled common fixed point results of integral type contractive mapping in ordered S-metric space. Moreover, we give an example to support our main result.

‎In this paper, based on [A. Razani, V. Rako$check{c}$evi$acute{c}$ and Z. Goodarzi, Nonself mappings in modular spaces and common fixed point theorems, Cent. Eur. J. Math. 2 (2010) 357-366.] a fixed point theorem for non-self contraction mapping $T$ in the modular space $X_rho$ is presented. Moreover, we study a new version of Krasnoseleskii's fixed point theorem for $S+T$, where $T$ is a cont...

Tonic physiological activity of RhoA/Rho kinase contributes to the maintenance of penile flaccidity through its involvement in the Ca(2+) sensitization of erectile tissue smooth muscle. The present study hypothesized that Rho kinase is also involved in the modulation of Ca(2+) entry induced by alpha(1)-adrenoceptor stimulation of penile arteries. Rat penile arteries were mounted in microvascula...

Allelic association between pairs of loci is derived in terms of the association probability rho as a function of recombination theta, effective population size N, linear systematic pressure v, and time t, predicting both rho(rt), the decrease of association from founders and rho(ct), the increase by genetic drift, with rho(t) = rho(rt) + rho(ct). These results conform to the Malecot equation, ...