Rho family of GTPases is an ubiquitiously expressed and evolutionarily conserved family of GTP binding proteins that regulate actin dynamics and intracellular signaling. Among the Rho family GTPases, three members RhoA, Rac1 and CDC42 have been well characterized. They each play pivotal roles in gene expression, cell proliferation, apoptosis and various cellular functions. They are driven by si...

The apical junctional complex (AJC), encompassing the tight junction (TJ) and adherens junction (AJ) plays a vital role in regulating epithelial cell differentiation and barrier function of simple epithelia. Both AJ and TJ are comprised of multiprotein complexes consisting of transmembrane proteins, which interact with the underlying cytoskeleton via cytoplasmic scaffold proteins. These interac...

A user’s data is represented by a finite-valued random variable. Given a function of the data, a querier is required to recover, with at least a prescribed probability, the value of the function based on a query response provided by the user. The user devises the query response, subject to the recoverability requirement, so as to maximize privacy of the data from the querier. Privacy is measure...

Cytokinesis in animal cells is powered by the cytokinetic apparatus, a ring of filamentous actin and myosin-2 that underlies the plasma membrane and closes between the separating chromosomes. Formation of the cytokinetic apparatus is at least partially dependent on the small GTPase, Rho. Similar to other small GTPases, Rho cycles between the active (GTP-bound) and inactive (GDP-bound) states. B...

In this paper, we consider double sequence iteration processes for strongly $rho$-contractive mapping in modular space. It is proved, these sequences, convergence strongly to a fixed point of the strongly $rho$-contractive mapping.

The paper considers the Riemann boundary value problem in half-plane class of functions that are $C(\rho)$-continuous with respect to weight $\rho(x)$, when function has infinite number zeros. Necessary and sufficient conditions for solvability established. If is solvable, solutions represented an explicit form.

Invasion of epithelial cells by Shigella, the causative agent of bacillary dysentery, is dependent upon the formation of characteristic membrane ruffles that engulf the bacteria in a macropinocytic-like process. We show here that Cdc42 and Rac GTPases, but not Rho;, are critical for actin polymerisation, whereas Rho; is necessary for the recruitment of ezrin and Src at the site of entry. Remark...