The aim of this study was to assess a novel approach to treating severe knee osteoarthritis by targeting synovial membrane, superficial articular cartilage, synovial fluid, and subchondral bone by combining intra-articular injections and intraosseous infiltrations of platelet rich plasma. We explored a new strategy consisting of intraosseous infiltrations of platelet rich plasma into the subcho...

Background  Many biomaterials are used during the open sinus lift surgery, beneath the elevated scheniderian membrane and maxillary sinus bony floor but the search for Ideal material continues. Methods  In the maxillary posterior atrophic ridges with the bone height less than four millimeters the open sinus lift surgery performed. The autologous Platelet-rich plasma (PRF) was used as the sol...

mefloquine (mfq), as a racemic mixture is used for the prophylaxis and treatment of malaria. stereoselective pharmacodynamic and pharmacokinetic differences have been observed for mfq. in the present study, the human blood was spiked with racemic mfq. the concentration of mfq enantiomers in various blood fractions including packed erythrocyte layer, platelet rich plasma and platelet poor plasma...

introduction: gold standard for alveolar cleft bone grafting is autogenous bone. advantage of adding the growth factors to the bone is established, so adding prf to the autogenous bone may have beneficial effects. methods:  platelet-rich plasma admixed with autogenous bone and as a biologic membrane over the bone grafted alveolar cleft was used. results:  autogenous bone in all (four cases) was...

Case Description- Three domestic short haired cats (2, 5 and 4 years of age) were presented to the Madras Veterinary College Teaching Hospital, with the history of large chronic, full thickness wounds on the right lateral cervical, left caudal forearm and right lateral thoracic region respectively. Etiology of the wounds was trauma in two cases and thermal burns in the third ca...

objective(s): platelet-rich plasma (prp) has recently emerged as a promising strategy in regenerative medicine due to its multiple endogenous growth factors. little is known about the role of prp as a promoter in chondrogenesis of human adipose derived stem cells (hadscs). the aim of this study was to determine whether prp may be considered as a natural and easy achievable source of growth fact...

the purpose of the present randomized clinical trial study was to compare the effectiveness of bovine porous bone mineral (bpbm) with and without plasma rich in growth factors (prgf) in the treatment of mandibular class ii furcation defects.in seven patients, nine pairs of symmetric buccal or lingual mandibular class ii furcation defects were treated. in each patient, one defect received bpbm (...

conclusions both l-prp and l-prf could be used to effectively promote the healing of articular cartilage defects of the knee. results mean macroscopic scores of the treated defects were higher than the controls at all sampling times with significant differences (p < 0.05) observed between l-prf treated and control defects (10.13 vs. 8.37) and l-prp treated and control defects (10 vs. 8.5) at 4 ...

BACKGROUND Platelet-rich plasma (PRP) contains various growth factors and appears to have a potential to promote tendon healing, but evidence is lacking regarding its effect on human tenocytes from rotator cuff tendons with degenerative tears. HYPOTHESIS Platelet-rich plasma stimulates cell proliferation and enhances matrix gene expression and synthesis in tenocytes isolated from human rotato...