The generation of complement-dependent chemotactic activity was demonstrated by herpes simplex virus (HSV) antigen, HSV antigen-antiviral antibody complexes, and HVS-infected cell lysates using the Boyden in vitro assay. In the presence of normal serum, chemotactic activity was generated by lysates of uninfected cells when nonspecific cell damage released chemotactic intracellular proteolytic e...

Uterine spiral arteries are extensively remodeled during placentation to ensure sufficient delivery of maternal blood the developing fetus. arterial remodeling is complex, as cells originating from both mother and conceptus interact at interface regulate extracellular matrix vasculature restructuring necessary for successful placentation. Despite this complexity, one mechanism critical artery t...

The acquisition of genetic abnormalities in human B-lineage acute lymphoblastic leukemia (ALL) culminates in the clonal expansion of bone marrow (BM)-derived leukemic blasts. However, the response of leukemic cells to signals transduced by the BM microenvironment is not completely understood. The present study describes a new human B-lineage ALL cell line designated BLIN-4 (B LINeage-4). BLIN-4...

Recent studies have reported that decreased T cell infiltrate alone, or co-ordinate with increased macrophage infiltrate, correlate with decreased survival in a range of cancers, including patients with pancreatic cancer. Importantly, in mouse models of pancreatic cancer, therapies that decrease tumor-associated macrophage infiltrates improve the response to chemotherapy, matching data in mamma...

IntroductionThis study aimed to analyse cervical lymphocytic populations in HIV+ and HIV− patients correlate different lesions with HIV viral load presence of high-risk HPV types.Material methodsA total 132 histological specimens from 40 72 were evaluated for CD4+ CD8+ T cell distribution, types, peripheral blood CD4+/CD8+ ratio.ResultsHigh-grade squamous intraepithelial (HSIL) carcinoma (SCC) ...

Marginal infiltrates arise from a wide variety of causes and according to the recent literature occur most commonly in association with chronic staphylococcal blepharitis. Marginal infiltrates often have a crescent form or coalesce to form a complete ring concentric to the limbus. On the other hand, the well-formed manifestation of an immunological process in the cornea, the so-called immunolog...

The acquisition of genetic abnormalities in human B-lineage acute lymphoblastic leukemia (ALL) culminates in the clonal expansion of bone marrow (BM)-derived leukemic blasts. However, the response of leukemic cells to signals transduced by the BM microenvironment is not completely understood. The present study describes a new human B-lineage ALL cell line designated BLIN-4 (B LINeage-4). BLIN-4...

PURPOSE To describe a case of peripheral ulcerative keratitis associated with type II cryoglobulinemia in the context of Hepatitis C infection. METHODS Case report and literature review. RESULTS A 36-year-old male patient presented to our emergency department with unilateral moderate pain in his right eye, associated with redness and photophobia. Medical background elicited a history of Hep...

INTRODUCTION The pathogenesis of nasal polyps is still not fully understood. AIM To analyze the topography and intensity of interleukin 1β (IL-1β), tumor necrosis factor α (TNF-α), cyclooxygenase 2 (COX-2), nitric oxide synthase 2 (NOS-2), and nuclear factor-κB (NF-κB) expressions in eosinophilic and neutrophilic polyps and in normal nasal mucosa. MATERIAL AND METHODS The study included spe...

This is a case report of Acanthamoeba as a causative agent of keratitis at the Department of Ophthalmology, University Hospital Rijeka. Delay in treatment led to an advanced stage of the disease with multiple complications. Initially, presented symptoms were similar to those of herpetic keratitis. In the mean time progression of the disease led to a cloudy cornea with a stromal ring infiltrate,...