BACKGROUND Almost all hepatic cancer cells have resistance to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis. c-FLIPL and RIP-1 are apoptotic negative regulatory factors. This study investigated the role of c-FLIPL and RIP-1 in hepatic cancer cell resistance to TRAIL-induced apoptosis. MATERIAL AND METHODS HepG2 cells were treated by TRAIL, RIP-1 siRNA, and/or...

We found that Rififylin/Carp2-deficient knockout mice were born at expected Mendelian ratios, were healthy and displayed no overt phenotype, and exhibited normal fertility (Figure S and Table S). This contrasts with both RIP-deficient mice and mice lacking several proteins implicated in K48-and/ or K63-linked ubiquitylation and regulation of TNFR–RIP signaling [,3,6–4]. Isolated wild-type (WT) ...

RIP matrices– shorthand for matrices which satisfy the restricted isometry property– appeared as a byproduct of Compressed Sensing; a method discovered by D. Donoho, E. Candès and T. Tao in 2004 with several applications in computer science. Besides their real world application, RIP matrices are interesting mathematical objects because, on the one hand, a random matrix has a negligible probabil...

We develop the general reconstruction scheme in two scalar model. The quintom-like theory which may describe (different) non-singular Little Rip or de Sitter cosmology is reconstructed. The number of scalar phantom dark energy models (with Little Rip cosmology or asymptotically de Sitter evolution) is presented. Stability issue of such dark energy cosmologies as well as the flow to fixed points...

In Neurospora crassa, DNA sequence duplications are detected and altered efficiently during the sexual cycle by a process known as RIP (repeat-induced point mutation). Affected sequences are subjected to multiple GC-to-AT mutations. To explore the pattern in which base changes are laid down by RIP we examined two sets of strains. First, we examined the products of a presumptive spontaneous RIP ...

One of the most important performance objectives for a localization system is positional accuracy. It is fundamental and essential to general location-aware services. The radio interferometric positioning (RIP) method [1] is an exciting approach which promises sub-meter positional accuracy. In this work, we would like to enhance the RIP method by dynamically selecting the best anchor nodes as b...

Although transgenic mice expressing murine B7-1 (mCD80) on their pancreatic beta cells under the rat insulin-1 promoter (RIP-mCD80(+) mice) rarely develop spontaneous beta cell destruction and diabetes, we have previously reported the transgene-dependent induction of profound insulitis and lethal diabetes following multiple low dose injections of the beta cell toxin streptozotocin (MLDS) in RIP...

Riparin I is an alkamide with potential anxiolytic activity in preclinical studies. The characterization and understanding of solid-state properties play an importance role in drug development. For this work, the solid state of five riparin I batches (RIP-1, RIP-2, RIP-3, RIP-4, and RIP-5), obtained by the same synthesis process, were characterized by Scanning Electron Microscopy (SEM), Differe...

Ribosome-inactivating proteins (RIPs), enzymes that are widely distributed in the plant kingdom, inhibit protein synthesis by depurinating rRNA and many other polynucleotidic substrates. Although RIPs show antiviral, antifungal, and insecticidal activities, their biological and physiological roles are not completely understood. Additionally, it has been described that RIP expression is augmente...