Dystrophic epidermolysis bullosa (DEB) is an inherited mechano-bullous disorder of skin caused by mutations in the type VII collagen gene. The lack of therapy for DEB provides an impetus to develop gene therapy strategies. However, the full-length 9-kilobase type VII collagen cDNA exceeds the cloning capacity of current viral delivery vectors. In this study, we produced a recombinant type VII m...

Disordered eating behavior (DEB) is correlated with development of eating disorders and other psychological illnesses. Adolescent females with Type-1diabetes (T1DM) are at higher risk for developing DEB and have a two-fold higher incidence of DEB than their non-diabetic counterparts. Individuals with T1DM have the unique ability to omit insulin as a weight reduction strategy. DEB in T1DM adoles...

Abstract Background Transarterial chemoembolization (TACE) improves survival in cirrhotic patients with intermediate-stage hepatocellular carcinoma (HCC). Drug-eluting bead (Deb)-TACE is associated a reduction liver toxicity and drug-related adverse effects compared chemotherapy-TACE. This retrospective paired cohort study compares the outcomes of DEB-TACE HCC greater than less 5 centimeters. M...

BACKGROUND This study is an outcome evaluation of the Drug-Eluting-Bead-Chemoembolization (DEB TACE) compared to conventional TACE (cTACE) with Cisplation and Lipiodol in patients with hepatocellular carcinoma (HCC) and Child-Pugh A Cirrhosis. MATERIAL/METHODS A comparison of interventional therapy with either cTACE or DEB-TACE of 22 patients each with unresectable HCC and Child-Pugh A Cirrho...

sodium/proton exchangers (nhx) are key players in plant responses to salinity and have a central role in establishing ion homeostasis. nhxs can be localized in tonoplast or plasma membranes, where they exchange sodium ions for protons, resulting in the removal of ions from the cytosol into vacuole or extracellular spaces. in the present study, the expression pattern of the gene encoding na+/h+ ...

BACKGROUND Hypertonic saline is routinely used to treat rises in intracranial pressure (ICP) post-traumatic head injury. Repeated doses often cause a hyperchloremic metabolic acidosis. We investigated the efficacy of 8.4% sodium bicarbonate as an alternative method of lowering ICP without generating a metabolic acidosis. METHODS We prospectively studied 10 episodes of unprovoked ICP rise in 7...

The effect of four water salinity levels (0.75, 5, 10 and 15 dS.m -1 ) on growth indices and physiological parameters in some wild pistachio (P. atlantica, P. atlantica subsp. kurdica, P. atlantica subsp. mutica and P. atlantica subsp. cabulica) were investigated under greenhouse conditions. Leaf dry weight was reduced to about 30-54% at ECw 10 dS.m -1 . Chemical analysis of shoot and root indi...

We examined whether repeated bouts of exercise could override growth hormone (GH) auto-negative feedback. Seven moderately trained men were studied on three occasions: a control day (C), a sequential exercise day (SEB; at 1000, 1130, and 1300), and a delayed exercise day (DEB; at 1000, 1400, and 1800). The duration of each exercise bout was 30 min at 70% maximal O2 consumption (VO2max) on a cyc...

The high sensitivity of Fanconi's anemia (FA) cells to drug induced DNA interstrand crosslinks (ICL) such as diepoxybutane (DEB) was used as a part of FA screening in the children with clinical suspicion of FA. The study considered a total of 66 children with the hematological and/or congenital phenotypic symptoms reminiscent of FA. Blood samples from patients with clinical suspicion of FA and ...

Hypernatremia is defined as plasma Na+ concentration above 145 meq/L (often due to absolute body water loss and not to total sodium excess). Nevertheless, when kidney damage is present, as occurs in renal diseases, hepatic cirrhosis and congestive heart failure, total body sodium can be increased. The present study evaluates the relationship between hypernatremia and response to anesthetic drug...