Historical control tumor data are useful in the interpretation of long-term rodent carcinogenicity bioassays, especially to assess the occurrence of rare tumors and marginally increased tumor incidences. The major prerequisites to compare historical control data with studies under evaluation are the validity and consistency of the respective databases. The RITA (Registry of Industrial Toxicolog...

BACKGROUND Internal thoracic arteries (ITAs) are frequently anastomosed to the coronary circulation for bypass grafting. The purpose of this research was to investigate in vivo the long-term morphofunctional changes of ITAs after their use as coronary artery bypass conduits, by comparing the morphological features and vasoreactivity of the grafted left ITA (LITA) with the native, nonharvested r...

Determining the taxonomic lineage of DNA sequences is an important step in metagenomic analysis. Short DNA fragments from next-generation sequencing projects and microbes that lack close relatives in reference sequenced genome databases pose significant problems to taxonomic attribution methods. Our new classification algorithm, RITA (Rapid Identification of Taxonomic Assignments), uses the agr...

The main objective of this study was to compare the performance of a portable impairment test device known as roadside impairment testing apparatus (RITA) with the field impairment tests (FIT) that are used at the roadside by UK police. One hundred and twenty two healthy volunteers aged 18-70 years took part in this two-period crossover evaluation. The volunteers received a dose of alcohol and ...

For the past three decades of research, p53 has been identified as one of the most targetable molecules for developing anticancer treatments. This tumor suppressor protein is involved in apoptosis, cell cycle arrest and senescence. Impairment of p53 function in tumors occurs either as a result of mutations in the TP53 gene itself or the abrogation of signaling pathways regulating p53 that are r...

Sensory-substitution prosthetic systems are based on the idea of substituting visual stimulation with stimulation from another intact sense such as audition or touch. Although such systems have been studied for almost 40 years (Bach-y-Rita 1968), they are still poorly understood. Here we ask whether we learn to perceive simple spatial properties using The vOICe (Meijer 1992), a system for visua...

Boris Keren, Oscar T. Suzuki, Marion Gérard-Blanluet, Dominique Brémond-Gignac, Monique Elmaleh, Luigi Titomanlio, Anne-Lise Delezoide, Maria Rita Passos-Bueno, and Alain Verloes* Clinical Genetic Unit, Department of Medical Genetics, APHP, Robert Debré University Hospital, Paris, France Human Genome Center, Department of Genetics and Evolution Biology, Institute of Biosciences, University of S...

Flavio Villani *, Veronica Pelliccia , Giuseppe Didato , Giovanni Tringali , Francesco Deleo , Rita Garbelli , Laura Rossini , Roberto Spreafico a Division of Clinical Epileptology and Experimental Neurophysiology, ‘‘Carlo Besta’’ Neurological Institute Foundation, Milan, Italy b Epilepsy Surgery Center ‘‘C. Munari’’, Niguarda Hospital, Milan, Italy Division of Neurosurgery III, ‘‘Carlo Besta’’...

Rita Isabel Lechuga and Ana Cristina Castro Milken Institute School of Public Health, George Washington University, Washington DC 20052, USA National Autonomous University of Mexico, Westhill Institute, Mexico City, Mexico Department of Health Sciences, University of York, Heslington, York YO10 5DD, UK Escuela de Kinesiologia, Clinica Alemana Universidad del Desarrollo, Santiago 7550000, Chile ...