Abstract When stress factors trigger transcriptional and metabolic changes, RNA interference (RNAi) is associated with gene expression regulation at the post-transcriptional levels. RDR, DCL AGO proteins contribute to these silencing processes during reactions plant development. An entire revision of maize genes was carried out prior experiments. In this study, transcript changes a total 4 ZmRD...

The Effect of Chalcone Isomerase (Chi) Gene Silencing on Flavonoids Content in Petunia hybrida using RNAi Technology

RNA interference (RNAi) is a promising strategy to suppress the expression of disease-relevant genes and induce post-transcriptional gene silencing. Their simplicity and stability endow RNAi with great advantages in molecular medicine. Several RNAi-based drugs are in various stages of clinical investigation. This review summarizes the ongoing research endeavors on RNAi in molecular medicine, de...

With siRNA-based drugs becoming established as a therapeutic modality, large companies are engaging in the field through deals and acquisitions, cardiovascular metabolic diseases among their targets.