We recently identified a novel human protein kinase, p160 ROCK, as a putative downstream target of the small GTPase Rho. Using the human ROCK cDNA as a probe, we isolated cDNA of two distinct, highly related sequences from mouse libraries. One encoded a mouse counterpart of human ROCK (ROCK-I), and the other encoded a novel ROCK-related kinase (ROCK-II). Like ROCK/ROCK-I, ROCK-II also bound to ...

Drilling into a rock massif is energetically extremely consumptive process. Hence the optimization of drilling regime with objective of energy consumption minimization, is very important. Proposed article discusses partial problem of this problem. During the drilling process it is useful to know the drilled rock type, whereas to particular drilled rock needs convenient drilling regime, which is...

protein serine/threonine kinase (ROCK), is one of the central regulatory molecules for cytoskeleton control and cell adhesion process. ROCK also involves in other cell functions such as apoptosis and tumor invasiveness. Rho kinase is thought to play an important role in a variety of cellar functions such as stress fiber formation, focal adhesion formation, cell aggregation, cell morphology, cyt...

In this work, the effect of rock bolt angle on the shear behavior of Rock Bridges is investigated using the particle flow code in two dimensions (PFC2D) for three different Rock Bridge lengths. Firstly, the calibration of PF2D is performed to reproduce the gypsum sample. Then the numerical models with the dimensions of 100 mm * 100 mm are prepared. The Rock Bridge is created in the middle of th...

No prior research has documented the different types of rock coatings in Yosemite Valley, despite the evident black streaks down Yosemite Falls, the light granitic rock exposed by recent rock falls contrasting with dark rock coatings, and the millions of visitors who have photographed the coated rocks of Yosemite. This paper identifies the types of rock coatings found on Half Dome, in Yosemite ...

Introduction: We have completed analysis of a new near-field rock count at the Mars Pathfinder landing site and determined that the previously published [1,2] rock count suggesting 16 % cumulative fractional area (CFA) covered by rocks is incorrect. The earlier value is not so much wrong (our new CFA is 20%), as right for the wrong reason: both the old and the new CFA’s are consistent with remo...

Original scientific paper Rock burst is a common serious geological hazard in underground engineering, which seriously affects the progress of projects. The mechanism of rock burst can be explained by the distribution law of rock fragments and its fractal characteristics. A simulation experiment of rock burst was conducted with the granite samples under a biaxial loading machine system to analy...

In prion diseases, synapse dysfunction, axon retraction and loss of neuronal polarity precede neuronal death. The mechanisms driving such polarization defects, however, remain unclear. Here, we examined the contribution of RhoA-associated coiled-coil containing kinases (ROCK), key players in neuritogenesis, to prion diseases. We found that overactivation of ROCK signaling occurred in neuronal s...

1 Department of Endocrinology and Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA, 2 GIM Foundation, Little Rock, AR, USA, 3 Department of Internal Medicine and Hospital Medicine, Christus Trinity Mother Frances Hospital, Tyler, TX, USA, 4 Department of Policy, University of Arkansas for Little Rock, Little Rock, AR, USA, 5 Tutwiler Clinic, Tutwiler, MS, USA...

This paper deals with the statistical analysis of the uniaxial compressive strength and of the elastic modulus of jointed rock masses under different confining pressures. Properties of the rock masses with different joint fabric, with and without gouge have been considered in the analysis. A large amount of experimental data of jointed rock masses from the literature has been compiled and used ...