Cancer-associated changes in cellular behavior, such as modified cell-cell contact, increased migratory potential, and generation of cellular force, all require alteration of the cytoskeleton. Two homologous mammalian serine/threonine kinases, Rho-associated protein kinases (ROCK I and II), are key regulators of the actin cytoskeleton acting downstream of the small GTPase Rho. ROCK is associate...

Radon gas is the largest natural source of human exposure to ionizing radiation and most of that exposure occurs in indoor air. Bedrock geology is an important factor in radon hazard evaluation of an area. The presence of rock types usually rich in uranium can be considered an indication of a potential radon hazard. In this study the average Ra activity concentration of the main rock types (ort...

In this paper, we aim to present a quantitative modeling for delineating the alteration zones and lithological units in the hypogene zone of Masjed-Daghi Cu-Au porphyry deposit (NW Iran) based on the drill core data. The main goal of this work is to apply Ordinary Kriging (OK) and concentration-volume (C-V) fractal model based on Cu grades in order to separate the different alteration zones and...

Introduction: Methane was first detected in the Matian atmosphere in 2003 [1-3], and its implications have been widely debated [e.g., 4-8]. Methane can be generated in terrestrial biological systems, and so is a potential indicator for past or present life (see e.g., [4,5]). However, methane can be produced anorganically (without intervention of life) in several sorts of terrestrial environment...

[1] Models of hydrothermal groundwater circulation can quantify limits to the role of hydrothermal activity in Martian crustal processes. We present here the results of numerical simulations of convection in a porous medium due to the presence of a hot intruded magma chamber. The parameter space includes magma chamber depth, volume, aspect ratio, and host rock permeability and porosity. A prima...

Based on a typical project in an altered rock area, this study carried out numerical simulations using the FLAC3D software to calculate changes stress field, deformation and plastic zone of surrounding during unsupported supported excavation water transfer tunnel. The degree alteration was considered as base point. following results were obtained: state, tunnel affected by different degrees alt...

The U.S. Geological Survey conducted an environmental assessment of 198 catchments in a 54,000-km area of central Colorado, much of which is on Federal land. The Colorado Mineral Belt, a northeast-trending zone of historical baseand precious-metal mining, cuts diagonally across the study area. The investigation was intended to test the hypothesis that degraded water and sediment quality are res...