Our civilization is based on metals, among other life supports. The existing ore deposits are becoming rapidly depleted by almost exponentially increasing demand and production and major new ore discoveries are needed. Mineral exploration is supported by modern tools and scientific ideas, but geological characteristics of orebodies and their rock associations have still to be visualized.The tim...

Sturzstroms are a rare category of rock avalanche that travel vast horizontal distances with only a comparatively small vertical drop in height. Their extraordinary mobility appears to be a consequence of sustained fluid-like behavior during motion, which persists even for driving stresses well below those normally associated with granular flows. One mechanism that may explain this temporary in...

Measuring the elastic modulus of in-situ rock masses over scales of tens of meters remains an important challenge in experimental rock mechanics. We present a new approach using ambient resonance measurements of freestanding rock masses to identify vibrational modes, which are then matched with numerical models implementing bulk, globally representative material properties. The result is an exp...

electrochemical properties of various rock-shaped-cuo/graphite (g) composites and monoclinic structure cuo nanoparticles as the cathode versus a zinc plate as the anode in a 4m naoh electrolyte were elucidated by electrochemical impedance spectroscopy (eis) and chronopotentiometry (cp) in a two electrode configuration cell. various values of g 9, 16 and 28 wt% were prepared and studied as catho...

There is an urgent need to identify new therapeutic opportunities for metastatic melanoma. Fragment-based screening has led to the discovery of orally available, ATP-competitive AKT kinase inhibitors, AT13148 and CCT129254. These compounds also inhibit the Rho-kinases ROCK 1 and ROCK 2 and we show they potently inhibit ROCK activity in melanoma cells in culture and in vivo. Treatment of melanom...

buckle folds are common traps for hydrocarbon in several contractional provinces. buckle folds form where stratified sequences rest a top salt or some other utterly weak rock as a decollemet zone in units with high competency contrasts by a compressive stress which acted along the length of the rock layers. an important parameter affecting buckle folding of a competent zone above a mobile decol...

Rho-kinase (ROCK) inhibition, broadly utilised in cardiovascular disease, may protect the blood-brain barrier (BBB) during thrombolysis from rt-PA-induced damage. While the use of nonselective ROCK inhibitors like fasudil together with rt-PA may be hindered by possible hypotensive side-effects and inadequate capacity to block detrimental rt-PA activity in brain endothelial cells (BECs), selecti...

Mining companies typically process all the material extracted from a mine site using processes which are extremely consumptive of energy and chemicals. Sorting the good material from the bad would effectively reduce required resources by leaving behind the bad material and only transporting and processing the good material. We use a relational influence diagram with an explicit utility model ap...

in this work, the mechanism for fracture of brittle substances such as rocks under a uniform normal tension is considered. the oriented straight micro-cracks are mostly created in all the polycrystalline materials resulting from the stress concentrations. the present work focuses on the interactions of the pre-existing micro-cracks, which can grow and propagate within a rock-like specimen. the ...