BACKGROUND Rosai-Dorfman is a rare disease that usually occurs in young adults. It is characterized with massive painless cervical lymphadenopathy and histiocyte proliferation. Isolated intracranial involvement is extremely rare. Our aim is to present a new rare case of extranodal Rosai-Dorfman disease that involved the right optic nerve in a 4-year-old boy. CASE DESCRIPTION A 4-year-old boy ...

any patient with bilateral lymphadenopathy especially in indian subcontinent is regarded as suffering from tuberculosis unless proved otherwise. this sometimes leads to unwarranted delay in correct diagnosis and management if there is ignorance regarding other rarer etiologies. rosai-dorfman disease (rdd) may present in the same manner and should always be kept on the back of the mind to help a...

Rosai-Dorfman disease is a rare benign histiocytic disorder that arises predominantly in lymph nodes with fever and malaise, but can affect various organs, with or without lymphadenopathy. Solitary extranodal skeletal lesions are extremely rare. Herein, we describe a case of isolated disease of thoracic spine, with vertebral body fracture. A 14-year-old girl presented with cervical back pain fo...

Rosai Dorfman disease is an uncommon benign condition presenting with massive enlargement of cervical lymph nodes. We describe one such young female patient with similar presentation who had an aggressive course with fatal outcome.

RDD (Rosai Dorfman disease) is a rare and benign histiocytic proliferative disorder of unknown etiology. FNAC (Fine-needle aspiration cytology) is a useful and reliable tool for the diagnosis of RDD, and as such, biopsy is avoidable.

Rosai-Dorfman disease is also known as sinus histiocytosis with massive lymphadenopathy. Extranodal Rosai-Dorfman disease has been reported in ~ 43% of cases; the most frequent extranodal sites - skin, soft tissue, bone, respiratory tract, and eye - are usually involved in association with lymphadenopathy. Lack of lymph node involvement is rare, especially when patients manifest renal disease. ...

Intracranial Rosai-Dorfman disease without systemic involvement is extremely rare. A 59-year-old woman presented with headaches. Magnetic resonance imaging revealed an enhancing posterior fossa convexity lesion with the dural tail sign. The preoperative diagnosis was meningioma. The histopathological examination revealed reactivity for S-100 and CD68 and non-reactivity for CD1a with emperipoles...

Rosai-Dorfman disease (RDD) is a rare benign proliferative disorder of histiocytes in the lymph nodes with or without extranodal involvement. RDD limited to the skin without nodal involvement, known as cutaneous Rosai-Dorfman disease, is very rare. We describe a 34-year-old female with RDD of the skin over the chest. A large nodule with satellite lesions was excised for histopathological examin...

Sinus histiocytosis with massive lymphadenopathy (SHML) was first described in 1969 by Rosai and Dorfman [1]. It is a rare inflammatory disorder with key clinicopathological characteristics such as emperipolesis and positive immunostaining for S-100 protein [2] and CD68. Rosai–Dorfman disease (RDD) is primarily manifested in the lymph nodes, yet extranodal disease has been reported in as many a...