Podosomes are actin-based membrane protrusions that facilitate extracellular matrix degradation and motility of invasive cells. Podosomes can self-organize into large rosette-like structures in Src-transformed fibroblasts, osteoclasts and some highly invasive cancer cells. However, the mechanism of this assembly remains obscure. In this study, we show that the suppression of Jun N-terminal kina...

BACKGROUND Spitz nevi demonstrate a diverse spectrum of morphologies. Recently, there have been two reported examples of Spitz nevi with rosette-like structures similar to Homer-Wright rosettes. Rosettes have also been described in melanomas and in a proliferative nodule arising in a congenital nevus. METHODS A retrospective review of 104 cases of Spitz nevi and variants (n = 51), pigmented s...

Groundnut (Arachis hypogaea) plants with rosette disease contain a manually transmissible virus, groundnut rosette virus (GRV), which depends on a luteovirus, groundnut rosette assistor virus (GRAV), for transmission by the aphid Aphis craccivora. No virus-like particles have been reported for GRV but infected plants yield infective ssRNA. Infected leaves also contain dsRNA with prominent elect...

ABSTRACT Analysis by triple-antibody sandwich enzyme-linked immunosorbent assay of groundnut samples from fields in two seasons from different regions of Malawi showed the absence of groundnut rosette assistor virus (GRAV) from some plants showing groundnut rosette disease symptoms and the presence of GRAV in some symptomless plants. Viruliferous Aphis craccivora collected from fields transmitt...

Osteosarcoma with epithelioid appearance and a rosette-like configuration is a rare, recently reported variation in osteogenic sarcoma, which is thought to be associated with a poor prognosis. We report an unusual pediatric case of rosette-forming epithelioid osteosarcoma with poor response to neoadjuvant chemotherapy and repeated local recurrence following surgical resection. A 6-year-old boy ...

To investigate the rosette formation properties of Plasmodium vivax, blood was sampled from 26 adult Thai patients admitted with acute P. vivax malaria and a predominance of trophozoite and schizont stages in their peripheral blood smears. In each case, P. vivax-infected cells formed spontaneous rosettes with two or more uninfected red blood cells. Rosette formation of P. vivax was dependent on...

Many morphogenetic movements during development require the formation of transient intermediates called rosettes. Within rosettes, cells are polarized with apical ends constricted towards the rosette center and nuclei basally displaced. Whereas the polarity and cytoskeletal machinery establishing these structures has been extensively studied, the extracellular cues and intracellular signaling c...

region πa2 (26,50) πa1 (13,98) Figure 7 – Phase Transition curves in (L,m) and (N,L) plane with the useful area for abstraction Ideally, if a ground problem lies in the mushy region and has solution, then a useful abstraction operator shall map it into an abstract problem lying in the YES region. On the contrary, if a ground problem lies in the mushy region and has no solutions, then a useful a...