The ryanodine receptors (RyRs) are a family of Ca2+ release channels found on intracellular Ca2+ storage/release organelles. The RyR channels are ubiquitously expressed in many types of cells and participate in a variety of important Ca2+ signaling phenomena (neurotransmission, secretion, etc.). In striated muscle, the RyR channels represent the primary pathway for Ca2+ release during the excit...

The systemic effects of physical activity are mediated by the release IL-6 and other myokines from contracting muscle. Although muscle has been extensively studied, information on cellular mechanisms is fragmentary scarce, especially regarding role Ca2+ signals. aim this study was to characterize main components signals in human skeletal cells during secretion stimulated mobilizing agonist ATP....

Ryanodine receptors (RyRs) are ion channels responsible for the fast release of Ca2+ from sarco/endoplasmic reticulum to cytosol and show a selectivity over monovalent cations. By utilizing recently developed multisite model in molecular dynamic simulations, we that multiple cations accumulate upper filter RyRs, small size high valence make it preferable K+ competition space this confined regio...

The purpose of this study was to determine if there are alterations in the dihydropyridine and/or ryanodine receptors that might explain the excitation-contraction uncoupling associated with eccentric contraction-induced skeletal muscle injury. The left anterior crural muscles (i.e., tibialis anterior, extensor digitorum longus, and extensor hallucis longus) of mice were injured in vivo by 150 ...