Cow's milk allergy affects approximately 2% of infants under 2 years of age. This review summarizes the recent advances in understanding its pathophysiology and immunological mechanisms. Apart from IgE-mediated atopic manifestations, T cell-mediated reactions have been demonstrated in infants with cow's milk allergy. The clinical spectrum ranges from immediate-type reactions, presenting with ur...

BACKGORUND Food allergy is a rare disorder among breastfeeding babies. OBJECTIVE Our aim was to identify responsible allergens in human milk. METHODS We studied babies developing allergic symptoms at the time they were breastfeeding. Skin prick tests (SPT) were performed with breast milk and food allergens. Specific IgE was assessed and IgE Immunoblotting experiments with breast milk were c...

INTRODUCTION Cow's milk protein allergy is common in infants from industrialised countries, but is rarely considered in developing countries due to its variable clinical presentation. CASE PRESENTATION We report on a Tanzanian male infant, who developed blood-stained stool when feeding fresh cow's milk at the age of three months. After an initial diagnosis of amoebiasis, possible cow's milk p...

BACKGROUND Peanut allergy is typically severe, lifelong, and prevalent. OBJECTIVE To identify factors associated with peanut sensitization. METHODS We evaluated 503 infants 3 to 15 months of age (mean, 9.4 months) with likely milk or egg allergy but no previous diagnosis of peanut allergy. A total of 308 had experienced an immediate allergic reaction to cow's milk and/or egg, and 204 had mo...

Background Food allergy affects 6-8% of children before the age of 5 and is a frequent cause of many allergic diseases. Sensitization in infancy predominantly occurs first to cow’s milk and egg white. It is estimated that 2 to 5 % of infants develop milk allergy. Food allergy is a known provoking cause of Atopic Dermatitis (AD) in a subset of affected children and triggers skin symptoms in abou...

Background Cow’s milk allergy is the most common food allergy among children. Previous studies have reported that up to 75% of children may tolerate baked milk goods. Various forms of baked milk challenges have been used in the literature such as muffins, pizza, and waffles. However, the food used for baked milk challenge is often prepared in a non-standardized manner by the parents at home, ra...

OBJECTIVE To determine if allergy to cows milk was responsible for symptoms in two children. DESIGN Single patient trial. SETTING General Practice in New Zealand. PARTICIPANTS Two children aged about 6 months INTERVENTION Alternating bottles of soya-based milk and cow's milk provided by neighbours over their back fence. MAIN OUTCOME MEASURES Presence of diarrhea, irritability, rash an...

BACKGROUND Immunoglobulin E-mediated allergy to cow's milk protein represents a major problem for infants who are not breast fed. A search for substitute milks revealed a cross-allergenicity to milk derived from goat and sheep but not to milk from a mare. We noted that the cow, goat and sheep species are both artiodactyls and ruminants, defining them as kosher animals, in contrast to the mare. ...

PURPOSE Specific oral immunotherapy (SOIT) using interferon-γ (IFN-γ) has been successful as a food allergy treatment. Interleukin-10 (IL-10)-producing regulatory B cells (Br1s) play a role in immune tolerance to food allergens. In addition, IFN-γ shows tolerogenic effects on allergen-induced Br1 responses. METHODS Eleven patients that were allergic to cow's milk and 12 milk-tolerant subjects...