BACKGROUND/AIMS Thyroid cancer accounts for about 1% of all cancer cases. Multikinase inhibitors like sunitinib (S) have a promising potential in thyroid cancer therapy. Therefore, the principal aim of this study was to investigate the impact of sunitinib on the secretion of cytokines of follicular thyroid cancer cells. METHOD The effects of irradiation (R), S, and their combination (R+S) on ...

Objective(s): The present study was aimed to investigate the influence of thoracic epidural blockade on hypoxia-induced pulmonary hypertension in rats. Materials and Methods: Forty eight Wistar rats were randomly divided into 4 equal groups, named normoxia hypoxia hypoxia/ ropivacaine and hypoxia/saline. Animals were placed in a hypoxia chamber and instrumented with epidural catheters at the t...

many species of tea (camellia sinensis) and cowslip (echium amoenum) are used in iranian traditional medicine. the aim of this study was to conduct the survey on the ability of iranian black tea and cowslip extracts on secretion of tumor necrosis factor-alpha (tnf-alpha) by non-infected and infected mouse macrophages. a macrophage infection model with legionella pneumophila and enzyme linked im...

Treatment of sensitive human myosarcoma cells (KYM-S) with exogenous tumor necrosis factor (r-TNF) resulted in the production of TNF by the cells. The newly synthesized cellular TNF was identified immunologically on Western blots and as a single 1.8-kilobase band on Northern blots. TNF synthesis began within 2 h of administration of the exogenous TNF in a dose-dependent manner. r-TNF also induc...

Endotoxin-stimulated blood cytokine responses have been widely used to describe compromised host defense mechanisms after trauma. We investigated whether blood cytokine production after endotoxin stimulation is able to define distinct trauma-induced alteration patterns and whether alteration patterns are associated with tumor necrosis factor (TNF) gene polymorphisms. In 48 patients undergoing j...

Background and objectives: Inflammatory bowel diseases (IBD) are among the most prevalent diseases in developed countries. In general, IL-6 and TNF-α are considered as the main causes of tissue damage in the intestine. Salvadora persica is a domestic and abundant plant growing in some central and southern areas of Iran. The main objective of the current study was to ev...

background: immune system disturbances have an important role in endometriosis which may lead to infertility. it seems that inflammatory cytokines specially tumor necrosis factor alpha (tnf-) which were produced by activated macrophages have an important role in pathology of endometriosis. based on this theory, anti tnf- drugs like pentoxifylline (px) are suggested as new drugs for endometrio...

One of the key features of tumor cells is the acquisition of resistance to apoptosis. Thus, novel therapeutic strategies that circumvent apoptotic resistance and result in tumor elimination are needed. One strategy to induce apoptosis is to activate death receptor signaling pathways. In the tumor microenvironment, stimulation of Fas, Death receptor 4 (DR4) and tumor necrosis factor receptor 1 (...

Background: According to previous studies, the effectiveness of interleukin-17 (IL-17) inhibitors was higher in anti-TNF-naïve patients with ankylosing spondylitis (AS) [1,2]. Netakimab (NTK) is a humanized anti-IL-17A antibody approved for treatment AS, psoriatic arthritis, moderate-to-severe plaque psoriasis Russia and Belarus. Objectives: To compare efficacy NTK anti-TNF-experienced active A...

objective(s): the present study was aimed to investigate the influence of thoracic epidural blockade on hypoxia-induced pulmonary hypertension in rats. materials and methods: forty eight wistar rats were randomly divided into 4 equal groups, named normoxia hypoxia hypoxia/ ropivacaine and hypoxia/saline. animals were placed in a hypoxia chamber and instrumented with epidural catheters at the th...