objective(s): chemoresistance remains the main causes of treatment failure and mortality in cancer patients. there is an urgent need to investigate novel approaches to improve current therapeutic modalities and increase cancer patients' survival. induction of drug efflux due to overexpression of                  p-glycoproteins is considered as an important leading cause of multidrug resis...

We have expressed and characterized the severe acute respiratory syndrome coronavirus (SARS-CoV) spike protein in cDNA-transfected mammalian cells. The full-length spike protein (S) was newly synthesized as an endoglycosidase H (endo H)-sensitive glycoprotein (gp170) that is further modified into an endo H-resistant glycoprotein (gp180) in the Golgi apparatus. No substantial proteolytic cleavag...

background: s1 radiculopathy is a high prevalence illness and its early diagnosis is of crucial importance. several reports have revealed the efficacy of magnetic stimulation in diagnosis of this condition. we conducted this study to compare mmep latency and mmep amplitude in patients with s1 radiculopathy and healthy controls in shohadaye tajreash hospital in 2007. materials and methods: this ...

Furin is involved in the endoproteolytic processing of various protein precursors implicated many diseases such as diabetes, obesity, atherosclerosis, cancer, Alzheimer’s disease and viral infection including COVID-19. Recently, cell entry SARS-CoV-2 was found to require sequential cleavage spike glycoprotein (S protein) at S1/S2 S2? sites. The site (PRRAR) can be cleaved by proprotein converta...