Safranal is a monoterpene aldehyde found in saffron (Crocus sativus L.) petals. It has been previously reported that safranal has a wide range of activities such as antioxidant and anti-inflammatory effects. In this study, we examined the effect of safranal on brain injuries in a transient model of focal cerebral ischemia. Transient focal cerebral ischemia was induced by middle cerebral artery ...

objective: several phytochemical agents have been known to exhibit a neuroprotective effect. among them, curcumin, linalool, rutin, safranal, and thymoquinonewere widely investigated and neuroprotective activity of each of them was shown by several studies. this work was planned to investigate whether different combinations of them could induce better neuroprotective effect against glucose/seru...

background: saffron is the dried stigmata of the flowers of saffron (crocus sativus l., iridaceae). saffron is well known for the treatment of gastric disorders in traditional medicine.   objectives: in the search for new potential antiulcer agents, the effects of the ethanol extract of saffron and its active constituents crocin and safranal as compared with omeprazole against gastric ulcer ind...

objective(s): quinolinic acid (qa)-mediated excitotoxicity has been widely used as a model for studying neurodegenerative disorders. recent studies suggested that saffron (crocus sativus) or its active metabolite, i.e. safranal, exerts pharmacological actions on central nervous system including anxiolytic, anticonvulsant, and neuroprotective properties. the present study aimed to investigate th...

objective: crocin and safranal, as the major constituents of saffron, have many biological activities. this study investigated the effects of crocin and safranal on yawning response induced by intracerebroventricular (i.c.v.) injection of histamine in rats. materials and methods: in ketamine/xylazine-anesthetized rats, a guide cannula was implanted in the right ventricle of the brain and yawnin...

Objectives: Crocin and safranal, the major constituents of saffron, exert neuroprotective effects. In the present study, we investigated the effects of crocin and safranal  (alone or in combination with insulin) on peripheral neuropathy in diabetic rats. Materials and Methods: Diabetes was induced by intraperitoneal (i.p.) injection of 60 mg/kg of streptozotocin (STZ) and confirmed by blood glu...

The main goal of this study is to propose saffron as a sustainable substitute crop with high added value in some Moroccan agricultural areas with low and erratic rainfalls for their socio-economical development. The quality of the saffron spice crop produced under different Moroccan environments has to be evaluated prior to recommendation for commercial production. For this purpose, saffron was...

This study was carried out to determine the effects of subchronic thinner inhalation on oxidant− antioxidant balance,the relation between toxicity and oxidative stress, a possible protective effect α-lipoic acid against toxicationin rats. Sprague−Dawley rats were divided into 4 groups as follows: control (Gr. I), safranal II), III), andthinner+safranal Gr. IV). Each group consisted 10 rats, las...

Saffron is considered as the most expensive spice in world. Due to low production, high demand and cost, saffron very prone adulteration for economic benefits while putting public health at risk. The significant characteristic determining quality of coloring strength (crocin content), which determined by measuring UV-Vis absorption 440 nm aqueous preparations this spice. Picrocrocin safranal ar...